SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

Financials

From the e-filed returns the IRS publishes as XML (latest three processing years; amended returns replace the original). PDF copies at the IRS.

Officers, directors and key employees

As listed on the 990 for the year ended June 30, 2025, highest compensation first.

Address and contacts

Address (IRS master file)

3525 JOHN HOPKINS CT STE 200, SAN DIEGO, CA 92121-1176

In care of

% JOANNA DAVIES

Principal officer (990 for 2024)

JOANNA DAVIES, 3525 JOHN HOPKINS CT STE 200, SAN DIEGO, CA 92121

Signed the 990

JOANNA DAVIES, President & CEO

Phone

(858) 200-7156

Website

www.sdbri.org

Return prepared by

Leaf & Cole LLP

California records

California keeps its own records of charities and corporations. Search them by EIN 46-3481092 or by the name SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE.

Attorney General, Registry of Charities and Fundraisers

Registration status and filed reports (CT-TR-1, RRF-1)

Secretary of State, bizfile Online

Corporation status, entity number, agent for service

Franchise Tax Board

Entity status letter (state tax exemption, good standing)

Mission

The SDBRI mission is to find new ways to predict and prevent cancer, diabetes, autoimmune disease, neurological disorders and HIV infection, and to accelerate medical advances that maintain health and improve quality of life.

Program accomplishments

• HIV-associated neurological disease: Currently, more than half of HIV patients have HIV-associated neurocognitive disorder (HAND). Although drugs to control HIV infection have been instrumental in preventing progression to AIDS, they do not protect from HAND, which is now on the rise as this patient population is aging. SDBRI scientists working on HAND have discovered a biological process that we believe is involved in accelerating the aging process in people with HIV, increasing their risk of dementia. SDBRI scientists are now focused on designing and testing strategies to stop that biological process for the purpose of preventing the onset of dementia. In addition, drug abuse, particularly methamphetamine, increases the number of cells that HIV likes to infect in the central nervous system, increasing the HIV reservoir and aggravating inflammation. SDBRI research is focused on how methamphetamine encourages cells in the brain to attract and provide a home for HIV infection. This information will then be used to design therapies to stop HIV from infecting cells in the brain. A Senior Staff Scientist from France and a Staff Scientist. From Malaysia received salary and benefits while being trained at SDBRI in a variety of cellular immunology and sterile techniques to better understand the effect of methamphetamine on HIV infection in experimental models.
  Expenses $2,155,607 · revenue $74,002
• Multiple Sclerosis:Multiple Sclerosis is a debilitating autoimmune disease in which immune cells travel to the brain and spinal cord and destroy the protective coating that surrounds nerve fibers. Without the protective coating nerves are unable to send messages to different parts of the body and this causes an array of disorders including numbness in hands and feet, muscle weakness, fatigue, and blurred vision. It is estimated that there are 2.3 million people with MS worldwide. The goal of our cutting-edge research at SDBRI is to identify ways to manipulate and strengthen blood vessels so that the cells that cause multiple sclerosis (MS) are unable to enter the brain. In particular we seek to understand how the integrity of blood vessels in the brain is regulated by: (i) proteins of the extracellular matrix (ECM) that surround cells, and (ii) environmental stimuli such as mild hypoxia. By understanding these mechanisms, we can design new therapeutic approaches aimed at increasing blood supply and reducing vascular leak, thereby making blood vessels better equipped to protect against neurological damage. A Staff Scientist from Bangladesh and a Postdoctoral Fellow from Nepal received salary & benefits while being trained at SDBRI in cellular, molecular and biochemical techniques to learn how blood vessels can be strengthened and repaired and how we can use that information to stop and reverse MS.
  Expenses $1,558,973
• Cancer:A major question in cancer treatment remains, why do some people respond to treatment and others dont. Finding new ways to detect and treat cancer could potentially lead to cures that are currently unavailable to the majority of patients. At SDBRI scientists are developing a new technology to identify previously unidentifiable cancer-specific targets that might be used to design novel cancer fighting drugs. A Postdoctoral Fellow from Japan received salary and benefits while being trained at SDBRI in a variety of cellular immunology and sterile techniques to better understand techniques to help diagnose and treat cancer.DNA replication and disease DNA replicates in a highly organized way in healthy cells. However, in unhealthy cells, DNA replication is mis-regulated. SDBRI scientists are working to understand how DNA replication is mis-regulated in human disease in the hopes of finding new therapeutic approaches to preventing and reversing diseases such as cancer.Cells in our bodies eat internal parts of themselves to maintain their own health. This process, known as autophagy (spokeno-to-foh-jee), is essential for removing toxic material that causes diseases such as neurodegeneration and cancer. In autophagy, components inside cells are placed in a trash bag called the autophagosome which looks like a balloon. The autophagosome then fuses with the cells incinerator to decompose the transported toxic material. Scientists at SDBRI are working to understand how these complicated events are controlled in the hopes that interventions in these pathways might lead to novel treatments for disease.
  Expenses $1,423,018
• HIV/AIDS: The World Health Organization recently estimated that 36.7 million people live with HIV/AIDS worldwide with 1 million HIV-related deaths every year. New infections are estimated at an alarming 1.8 million worldwide. Developing a successful HIV vaccine is a major global health initiative. Research at SDBRI is focused on introducing novel designs to create an HIV vaccine that more people respond to. The SDBRI strategy of using HIV virus-like particles (VLPs) and mRNA as a vaccine platform is showing great promise. In addition, SDBRI scientists have designed ways to identify factors that help the immune system respond to HIV vaccines. This is very important because it might allow us to enhance the vaccine making it work in more people. SDBRI continues to participate in a multi-organization HIV vaccine research program. Our investigators work with scientists across the U.S. and in several foreign countries, including The Netherlands and Malaysia. A Staff Scientist from Malaysia received salary & benefits while being trained at SDBRI in a variety of cellular, molecular and biochemical techniques to better understand the human response to vaccines.
  Expenses $1,160,489
• Parkinsons Disease:Parkinsons disease (PD) is a neurodegenerative disorder that affects approximately 1% of the population over the age of 60. In the U.S. alone about 50,000 new cases are reported annually. It is believed that PD is caused by a combination of environmental and genetic factors. Scientists at SDBRI are working on the idea that allergic reactions represent an important environmental component in making people more susceptible to the development of PD. If this is true, components of the allergic response might be used as novel therapeutic targets to prevent PD or reduce its progression.
  Expenses $1,113,358
• Allergy and Asthma Severe asthma is a rising health problem affecting millions of Americans with no current curative solutions. It is characterized by persistent airway inflammation and corticosteroid resistance. The study conducted at SDBRI aims to understand why some patients do not respond to standard asthma therapeutics, focusing on an immune cell type discovered by SDBRI investigators. These studies will teach us how pathogenic cells are generated in asthma and how these pathogenic cells interact with other immune cells subsets to curtail allergic airway inflammation and asthma. Findings could establish improved predictors for patient stratification, leading to more targeted therapies for asthma patients.
  Expenses $637,878
• SYSTEMATIC LUPUS ERYTHEMATOSUS (SLE):SLE is caused by the immune system as it attacks the bodys tissue. Although there is a clear genetic predisposition to SLE, environmental factors also contribute to disease development. Ongoing work at SDBRI is focused on how genetic factors combine with virus infection and silica inhalation to cause SLE. It is hoped that understanding how the combination of these elements contribute to the development of SLE will provide information that can be used to develop therapies that block these interactions and the resulting disease.
  Expenses $613,151

What it must file and when

IRS records say it files Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N. Its accounting year ends in June, so each return is due on the 15th day of the 5th month after that.

IRS record

EIN

46-3481092

Tax-exempt status

501(c)(3): Charitable, religious, educational or scientific organization

Foundation status

Publicly supported organization (170(b)(1)(A)(vi))

Donations deductible (Pub 78)

Public charity, 50% deduction limit

Exempt since

2014

Accounting year ends

June

Files

Form 990 or 990-EZ

Category (NTEE)

Voluntary health associations and medical disciplines (G30)

Assets (IRS master file)

$13,648,150

Income (IRS master file)

$8,921,973

Filing history

990-N: the IRS bulk file holds only the latest e-Postcard per organization; earlier years come from archived copies of that file since 2020 and can have gaps (the IRS e-Postcard search lists every one). 990, 990-EZ, 990-PF, 990-T: every e-filed return in the IRS e-file index since 2019; XML for the latest three processing years, amounts from the IRS Statistics of Income extracts before that. PDF copies and determination letters at the IRS (search EIN 46-3481092).

Questions about SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

What is the EIN of SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE?

The employer identification number (EIN) of SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE is 46-3481092.

Is SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE tax-exempt?

Yes. The IRS lists it as tax-exempt under section 501(c)(3) since 2014.

Are donations to SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE tax-deductible?

Yes. It is listed in IRS Publication 78 (Public charity, 50% deduction limit).

Which annual return does SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE file?

Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N.

When is the next return of SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE due?

The return for tax year 2025 (the year ending June 30, 2026) is due November 16, 2026. Form 8868 extends it by six months; the 990-N cannot be extended.

When did SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE last file with the IRS?

The latest return in the IRS public files is the 990 for the year ended June 2025.

Who is the principal officer of SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE?

The 990 for the year ended June 30, 2025 names JOANNA DAVIES.

Who are the officers and directors of SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE?

The 990 for the year ended June 30, 2025 lists 14 people; 8 received compensation from the organization, the highest $210,953 (JAMES BINLEY, Professor).

How much revenue does SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE have?

On its 990 for the year ended June 30, 2025 it reported revenue of $8,921,973, expenses of $9,347,122 and total assets of $13,648,150 at year end.

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