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Nonprofit · EIN 52-2337019

HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE

Tax-exempt · WASHINGTON, DC 20005

Financials

$6.3M$6.5M2023$5.9M$5.8M2024
Revenue Expenses · by fiscal year end
Financials of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE by year, from its e-filed returns
Year endedFormRevenueExpensesNet incomeTotal assetsLiabilitiesNet assets
December 31, 2024990$5,906,429$5,840,464$65,965$10,839,257$3,958,978$6,880,279
December 31, 2023990$6,346,368$6,504,180-$157,812$10,423,827$3,872,730$6,551,097
Financial details: 990 for the year ended December 31, 2024

Revenue

Contributions, gifts and grants
$5,652,715
of which government grants
$627,607
Membership dues
$1,509,028
Program service revenue
$700
Investment income
$253,014
Net gain from sales of assets
-$13,965
Other revenue
$0

Expenses

Grants and similar amounts paid
$996,017
Compensation of officers, directors and key employees
$574,466
Other salaries and wages
$1,532,092
Salaries, compensation and benefits (total)
$2,446,952
Professional fundraising fees
$0
Accounting fees
$58,793
Occupancy
$328,753
Travel
$325,437
Program services (functional)
$4,786,846
Management and general (functional)
$965,521
Fundraising (functional)
$88,097

Balance sheet and other

Total assets, start of year
$10,423,827
Total assets, end of year
$10,839,257
Total liabilities, end of year
$3,958,978
Net assets, end of year
$6,880,279
Land, buildings and equipment
$69,750
Publicly traded securities
$8,263,367
Net assets without donor restrictions
$6,611,028
Net assets with donor restrictions
$269,251
Gross receipts
$7,244,807
Employees
17
Volunteers
300
Year formed
2001
State of legal domicile
DC

From the e-filed returns the IRS publishes as XML (latest three processing years; amended returns replace the original). PDF copies at the IRS.

Officers, directors and key employees

As listed on the 990 for the year ended December 31, 2024, highest compensation first.

NameTitleHours / weekCompensationOther / benefits
DR SYRIL PETTITEXECUTIVE DIRECTOR
Officer
37.5$323,669$23,357
MS BETH-ELLEN BERRYCHIEF FINANCIAL OFFICER
Officer
10$220,749$20,631
DR MICHELLE EMBRYASSOCIATE DIRECTOR
Key employee
37.5$211,284$16,156
DR RAEGAN O'LONESR. PROGRAM ADVISOR
Highest-paid employee
37.5$153,639$22,320
DR CONNIE JIANGSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$145,791$29,240
DR SANDRINE DEGLINSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$140,350$20,946
MS JENNIFER PIERSONASSOC. DIR. PROGRAM DEV & RES
Highest-paid employee
37.5$144,194$13,981
DR LUCILIA PEREIRA MOURIESSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$132,555$10,547
DR CAROLE L YAUKCHAIR
Trustee or director, Officer
2$0$0
PROF RUTH A ROBERTSPAST-CHAIR
Trustee or director, Officer
2$0$0
DR NINA HALLMARKVICE-CHAIR
Trustee or director, Officer
2$0$0
DR GARY MINSAVAGEPRESIDENT
Trustee or director, Officer
2$0$0
DR ANTHONY HOLMESPAST-PRESIDENT
Trustee or director, Officer
2$0$0
DR WARREN M CASEYVICE-PRESIDENT
Trustee or director, Officer
2$0$0
DR JOSE E MANAUTOUTREASURER
Trustee or director, Officer
2$0$0
28 more people on this return
NameTitleHours / weekCompensation
DR KARISSA ADKINSTRUSTEE
Trustee or director
2$0
DR TARA BARTON-MACLARENTRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR ROGER CHAMMASTRUSTEE
Trustee or director
2$0
DR MYRTLE DAVISTRUSTEE
Trustee or director
2$0
DR DORIT DONOVIELTRUSTEE
Trustee or director
2$0
DR DAVID L EATONTRUSTEE
Trustee or director
2$0
DR PATRICIA ESCOBARTRUSTEE
Trustee or director
2$0
DR MICK FELLOWSTRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR ROLAND FROETSCHLTRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR SARAH A HUGHESTRUSTEE
Trustee or director
2$0
DR YASU KANDATRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR ROBERT LANDSIEDELTRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR JESSICA LAROCCATRUSTEE
Trustee or director
2$0
DR ELISE MADISON LEWISTRUSTEE
Trustee or director
2$0
DR ADAM LILLICRAPTRUSTEE
Trustee or director
2$0
DR GRAEME MOFFATTRUSTEE
Trustee or director
2$0
DR ELIANA ROSA MUNARRIZTRUSTEE
Trustee or director
2$0
DR ROSE OMARITRUSTEE
Trustee or director
2$0
DR GLADYS OUEDRAOGOTRUSTEE (FROM JUN '24)
Trustee or director
2$0
DR MARC PALLARDYTRUSTEE
Trustee or director
2$0
DR TRACEY L PAPENFUSSTRUSTEE (TO JUN '24)
Trustee or director
2$0
DR STEFAN PFUHLERTRUSTEE
Trustee or director
2$0
DR HANS SANDERSONTRUSTEE
Trustee or director
2$0
DR YUKO SEKINOTRUSTEE (TO JUN '24)
Trustee or director
2$0
DR JUSTIN TEEGUARDENTRUSTEE
Trustee or director
2$0
DR JEAN-PIERRE VALENTINTRUSTEE
Trustee or director
2$0
DR MARTIN VAN DEN BERGTRUSTEE
Trustee or director
2$0
DR DOUGLAS C WOLFTRUSTEE (TO JUN '24)
Trustee or director
2$0
990 for the year ended December 31, 2023: 43 people
NameTitleHours / weekCompensationOther / benefits
DR SYRIL PETTITEXECUTIVE DIRECTOR
Officer
37.5$307,517$52,902
MS BETH-ELLEN BERRYCHIEF FINANCIAL OFFICER
Officer
10$215,419$16,004
DR MICHELLE EMBRYASSOCIATE DIRECTOR
Key employee
37.5$194,790$18,053
DR CONNIE JIANGSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$136,057$26,358
DR RAEGAN O'LONESR. PROGRAM ADVISOR
Highest-paid employee
37.5$135,969$21,850
DR SANDRINE DEGLINSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$131,802$19,231
MS JENNIFER PIERSONASSOC. DIR. PROGRAM DEV & RES
Highest-paid employee
37.5$134,756$13,255
DR LUCILIA PEREIRA MOURIESSR. SCIENTIFIC PROGRAM MGR
Highest-paid employee
37.5$126,015$10,047
PROF RUTH A ROBERTSCHAIR
Trustee or director, Officer
2$0$0
DR MARTIN VAN DEN BERGPAST CHAIR
Trustee or director, Officer
2$0$0
DR ANTHONY HOLMESPRESIDENT
Trustee or director, Officer
2$0$0
DR JON C COOKPAST PRESIDENT (TO FEB '23)
Trustee or director, Officer
2$0$0
DR DAVID L EATONTREASURER
Trustee or director, Officer
2$0$0
DR PAMELA J SPENCERSECRETARY (TO JAN '23)
Trustee or director, Officer
2$0$0
DR KARISSA ADKINSTRUSTEE
Trustee or director
2$0$0
DR WARREN M CASEYTRUSTEE
Trustee or director
2$0$0
DR ROGER CHAMMASTRUSTEE
Trustee or director
2$0$0
DR MYRTLE DAVISTRUSTEE
Trustee or director
2$0$0
DR DORIT DONOVIELTRUSTEE (FROM JUN '23)
Trustee or director
2$0$0
DR PATRICIA ESCOBARTRUSTEE
Trustee or director
2$0$0
DR NINA HALLMARKTRUSTEE
Trustee or director
2$0$0
DR SARAH A HUGHESTRUSTEE
Trustee or director
2$0$0
DR ELKE JENSENTRUSTEE (FROM JUN '23)
Trustee or director
2$0$0
DR JESSICA LAROCCATRUSTEE (FROM JUN '23)
Trustee or director
2$0$0
DR JERRY S H LEETRUSTEE (TO JUN '23
Trustee or director
2$0$0
DR ELISE MADISON LEWISTRUSTEE (FROM JUN '23)
Trustee or director
2$0$0
DR ADAM LILLICRAPTRUSTEE
Trustee or director
2$0$0
DR JOSE E MANAUTOUTRUSTEE
Trustee or director
2$0$0
DR CHARLENE A MCQUEENTRUSTEE (TO JUN '23
Trustee or director
2$0$0
DR GARY MINSAVAGETRUSTEE
Trustee or director
2$0$0
DR GRAEME MOFFATTRUSTEE
Trustee or director
2$0$0
DR ELIANA ROSA MUNARRIZTRUSTEE
Trustee or director
2$0$0
DR ROSE OMARITRUSTEE
Trustee or director
2$0$0
DR MARC PALLARDYTRUSTEE
Trustee or director
2$0$0
DR TRACEY L PAPENFUSSTRUSTEE
Trustee or director
2$0$0
DR STEFAN PFUHLERTRUSTEE
Trustee or director
2$0$0
DR HANS SANDERSONTRUSTEE
Trustee or director
2$0$0
DR YUKO SEKINOTRUSTEE
Trustee or director
2$0$0
DR KATHLEEN SHELTONTRUSTEE (TO FEB '23)
Trustee or director
2$0$0
DR JUSTIN TEEGUARDENTRUSTEE (FROM JUN '23)
Trustee or director
2$0$0
DR JEAN-PIERRE VALENTINTRUSTEE
Trustee or director
2$0$0
DR DOUGLAS C WOLFTRUSTEE
Trustee or director
2$0$0
DR CAROLE L YAUKTRUSTEE
Trustee or director
2$0$0

Address and contacts

Address (IRS master file)
740 15TH ST NW STE 600, WASHINGTON, DC 20005-1053
In care of
% KELLY L PARKER
Principal officer (990 for 2024)
SYRIL PETTIT, 740 15TH STREET NW 600, WASHINGTON, DC 20005
Signed the 990
SYRIL PETTIT, EXECUTIVE DIRECTOR
Phone
(202) 659-8404
Return prepared by
JOHNSON LAMBERT LLP

Mission

THE HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE (HESI) IS A NONPROFIT INSTITUTION WHOSE MISSION IS TO ENGAGE SCIENTISTS FROM ACADEMIA, GOVERNMENT, INDUSTRY, NONPROFIT, AND OTHER RESEARCH INSTITUTIONS TO IDENTIFY AND RESOLVE GLOBAL HEALTH AND ENVIRONMENTAL ISSUES.

990 for the year ended December 31, 2024

Program accomplishments

  • EMERGING SYSTEMS TOXICOLOGY FOR THE ASSESSMENT OF RISK (ESTAR): THE MISSION OF THIS COMMITTEE IS TO DEVELOP AND DELIVER INNOVATIVE SYSTEMS TOXICOLOGY APPROACHES FOR RISK ASSESSMENT. THIS INCLUDES THE ADOPTION OF NEW TRANSLATIONAL AND PREDICTIVE TOOLS THAT GUIDE DECISION-MAKING BASED ON MECHANISTIC UNDERSTANDING OF TOXICOLOGICAL RESPONSE, ENGAGING THE GLOBAL SCIENTIFIC COMMUNITY TO PROMOTE INTERNATIONAL ACCEPTANCE OF GENOMIC BIOMARKERS FOR DECISION-MAKING, AND IDENTIFYING AND CHARACTERIZING BIOFLUID AND TISSUE-BASED GENOMIC BIOMARKERS FOR TOXICOLOGY. THE COMMITTEE HAS SIX ACTIVE PROJECTS, INCLUDING THE OMICS FOR ASSESSING SIGNATURES FOR INTEGRATED SAFETY (OASIS) CONSORTIUM, WHICH IS INVESTIGATING THE USE OF CELL PAINTING AND TRANSCRIPTOMICS FROM IN VITRO MODELS AND COMPARING THEM TO EXISTING RAT IN VIVO DATA. ANOTHER PROJECT IS EVALUATING THE USE OF ERROR CORRECTED SEQUENCING TO DETECT CLONAL EXPANSION INDUCED BY NON-GENOTOXIC CARCINOGENS. EXISTING PROJECTS HAVE MADE GREAT PROGRESS. THE TGX-DDI PROJECT COMPLETED ITS MULTI-SITE TRIAL FOR QUALIFICATION, SUBMITTED A FINAL PACKAGE TO THE FDA BIOMARKER QUALIFICATION PROGRAM, AND SUBMITTED A MANUSCRIPT SUMMARIZING THE RING TRIAL. THE COMMITTEE PUBLISHED THREE MANUSCRIPTS BY END OF YEAR AND HAS PRESENTED AT FOUR SCIENTIFIC MEETINGS.
    Expenses $857,866
  • CARDIAC SAFETY TECHNICAL COMMITTEE: THE MISSION OF THE CARDIAC SAFETY TECHNICAL COMMITTEE IS TO IMPROVE PUBLIC HEALTH BY REDUCING UNANTICIPATED CARDIOVASCULAR-RELATED ADVERSE EFFECTS FROM DRUGS OR CHEMICALS AND DEVELOP INNOVATIVE APPROACHES TO SUPPORT EARLY DETECTION AND PREDICTION AS WELL AS IMPROVED UNDERSTANDING OF CARDIOVASCULAR TOXICOLOGY AND PATHOBIOLOGY. IN 2024, THE COMMITTEE CONTINUED TO SPONSOR PROJECTS ADDRESSING CARDIOVASCULAR SAFETY TESTING, PUBLISHED SIX SCIENTIFIC MANUSCRIPTS IN A PEER-REVIEWED TECHNICAL JOURNAL BASED ON THE COMMITTEE'S RESEARCH AND PRESENTED 4 TIMES AT PUBLIC SCIENTIFIC MEETINGS. AN ADDITIONAL 4 MANUSCRIPTS ARE IN PROGRESS. KEY PROJECTS INCLUDED CONTINUATION OF A NEW STUDY TO EXPLORE DRUG-INDUCED BLOOD PRESSURE CHANGES, A STUDY TO IDENTIFY BIOMARKERS OF BLEEDING DISORDERS, PROJECT PLANNING TO EXPLORE CARDIAC FUNCTION AND SODIUM CHANNEL BLOCK, AND COMPLETION OF DATA ANALYSIS FOR A NEW STUDY TO EXPLORE USE OF CARDIAC STEM CELLS TO PREDICT TOXICITY. THE COMMITTEE ALSO COMPLETED THEIR SUPPORT OF ONE GRANT AWARDED THROUGH FDA AND NIH IN SUPPORT OF A STRATEGIC FRAMEWORK TO ENHANCE THE USE OF MECHANISTIC STUDIES TO PREDICT POTENTIAL CARDIAC RISKS FOR PHARMACEUTICALS. A SECOND GRANT THROUGH FDA AND NIH CONTINUED WORK ASSESSING VARIABILITY AND REPRODUCIBILITY IN ASSAYS TO TEST FOR DRUG INDUCED CARDIAC TOXICITY. THE GRANT INCLUDES SUBCONTRACTS AT SEVERAL LABORATORIES IN THE US AND EUROPE.
    Expenses $626,945 · grants $3,835
  • GENETIC TOXICOLOGY TECHNICAL COMMITTEE: THE GENETIC TOXICOLOGY TECHNICAL COMMITTEE (GTTC) ADVANCES THE INTERPRETATION AND APPLICATION OF GENETIC TOXICOLOGY TESTING TO IMPROVE HUMAN HEALTH RISK ASSESSMENT AND FOSTER INNOVATIVE TESTING STRATEGIES. WITH NINE WORKING GROUPS AND 28 PROJECT TEAMS, GTTC COORDINATES COLLABORATIVE RESEARCH BY PRIORITIZING, DESIGNING, AND EXECUTING APPLIED GENETIC TOXICOLOGY STUDIES. THE COMMITTEE SUPPORTS EXTERNAL WORKSHOPS ON CRITICAL TOPICS SUCH AS NITROSAMINE TESTING AND QUANTITATIVE DOSERESPONSE ANALYSIS, FUNDS NOVEL EXPERIMENTAL STUDIES (E.G., TO EVALUATE AND OPTIMIZE SEQUENCING AND ASSAY METHODS), AND LEADS EDUCATION AND OUTREACH INITIATIVES. GTTC ALSO PROVIDES PROFESSIONAL DEVELOPMENT THROUGH COMPETITIVE TRAVEL AND TRAINING AWARDS THAT SUPPORT EARLY-CAREER SCIENTISTS IN BUILDING SKILLS, PRESENTING RESEARCH, AND ENGAGING WITH THE SCIENTIFIC COMMUNITY.
    Expenses $419,991 · grants $26,670
  • BOTANICAL SAFETY CONSORTIUM; IMMUNOTOXICOLOGY; PROTEIN ALLERGENICITY; ECO RISK; DEV & REPRODUCTIVE TOX; THRIVE; CT TRACS; PROTAC; UVCB; ENV EPI RA; ACSA 2; PB/PK; COMMUNICATIONS AND OUTREACH; GRATC; CORA OTOTOXICITY; EMERGING ISSUES CMTE; ADC; CEEH/CTS; RA 21ST CENTURY; NEOUROTOX BIOMARKERS; ANNUAL MEETING; PROG STRATEGY & STEWARDSHIP; EXTERNAL ADVISORY; PROMETHIUS BIOME; BIOACCUMULATION; NA FACTS; FAST FUND; HESI HELPS.
    Expenses $2,882,044 · grants $965,512 · revenue $700

What it must file and when

IRS records say it files Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N. Its accounting year ends in December, so each return is due on the 15th day of the 5th month after that.

Tax yearYear endedDueIRS public records
2025December 31, 2025May 15, 2026Not on file
2024December 31, 2024May 15, 2025990 on file
2023December 31, 2023May 15, 2024990 on file

IRS record

EIN
52-2337019
Tax-exempt status
501(c)(3): Charitable, religious, educational or scientific organization
Foundation status
Publicly supported organization (170(b)(1)(A)(vi))
Donations deductible (Pub 78)
Public charity, 50% deduction limit
Exempt since
2002
Accounting year ends
December
Files
Form 990 or 990-EZ
Assets (IRS master file)
$10,839,257
Income (IRS master file)
$7,244,807

Filing history

FormYear endedRevenueExpensesAssetsReturn
990December 2024$5,906,429$5,840,464$10,839,257XML
990December 2023$6,346,368$6,504,180$10,423,827XML
990December 2022$4,975,112$4,925,372$9,947,407IRS
990December 2021–––IRS
990December 2020–––IRS
990December 2018–––IRS

990-N: the IRS bulk file holds only the latest e-Postcard per organization; earlier years come from archived copies of that file since 2020 and can have gaps (the IRS e-Postcard search lists every one). 990, 990-EZ, 990-PF, 990-T: every e-filed return in the IRS e-file index since 2019; XML for the latest three processing years, amounts from the IRS Statistics of Income extracts before that. PDF copies and determination letters at the IRS (search EIN 52-2337019).

Questions about HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE

What is the EIN of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE?
The employer identification number (EIN) of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE is 52-2337019.
Is HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE tax-exempt?
Yes. The IRS lists it as tax-exempt under section 501(c)(3) since 2002.
Are donations to HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE tax-deductible?
Yes. It is listed in IRS Publication 78 (Public charity, 50% deduction limit).
Which annual return does HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE file?
Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N.
When is the next return of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE due?
The return for tax year 2025 (the year ending December 31, 2025) is due May 15, 2026. Form 8868 extends it by six months; the 990-N cannot be extended.
When did HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE last file with the IRS?
The latest return in the IRS public files is the 990 for the year ended December 2024.
Who is the principal officer of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE?
The 990 for the year ended December 31, 2024 names SYRIL PETTIT.
Who are the officers and directors of HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE?
The 990 for the year ended December 31, 2024 lists 43 people; 8 received compensation from the organization, the highest $323,669 (DR SYRIL PETTIT, EXECUTIVE DIRECTOR).
How much revenue does HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE have?
On its 990 for the year ended December 31, 2024 it reported revenue of $5,906,429, expenses of $5,840,464 and total assets of $10,839,257 at year end.

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