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Nonprofit · EIN 13-3859563

ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN

Also known as ALZHEIMERS RESEARCH FDN FISHER CEN

Tax-exempt · NEW YORK, NY 10022

Financials

$10.5M$6.7M2023$14.5M$22.5M2024
Revenue Expenses · by fiscal year end
Financials of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN by year, from its e-filed returns
Year endedFormRevenueExpensesNet incomeTotal assetsLiabilitiesNet assets
December 31, 2024990$14,515,618$22,477,077-$7,961,459$36,263,186$14,243,764$22,019,422
December 31, 2023990$10,469,067$6,723,337$3,745,730$33,358,648$6,303,189$27,055,459
Financial details: 990 for the year ended December 31, 2024

Revenue

Contributions, gifts and grants
$13,092,793
Program service revenue
$3,085
Investment income
$1,417,748
Net gain from sales of assets
$841,480
Other revenue
$1,992

Expenses

Grants and similar amounts paid
$19,479,990
Compensation of officers, directors and key employees
$373,510
Other salaries and wages
$661,616
Salaries, compensation and benefits (total)
$1,201,242
Professional fundraising fees
$0
Legal fees
$38,295
Accounting fees
$257,283
Occupancy
$250,896
Travel
$6,704
Depreciation
$9,204
Program services (functional)
$20,636,769
Management and general (functional)
$1,262,370
Fundraising (functional)
$577,938

Balance sheet and other

Total assets, start of year
$33,358,648
Total assets, end of year
$36,263,186
Total liabilities, end of year
$14,243,764
Net assets, end of year
$22,019,422
Land, buildings and equipment
$40,046
Publicly traded securities
$28,987,964
Net assets without donor restrictions
$21,948,408
Net assets with donor restrictions
$71,014
Gross receipts
$17,116,383
Employees
11
Volunteers
10
Year formed
1995
State of legal domicile
NY

From the e-filed returns the IRS publishes as XML (latest three processing years; amended returns replace the original). PDF copies at the IRS.

Officers, directors and key employees

As listed on the 990 for the year ended December 31, 2024, highest compensation first.

NameTitleHours / weekCompensationOther / benefits
LUCRETIA HOLDENEXECUTIVE DIRECTOR
Officer
40$336,398$37,112
REBECCA A LIBEDOPERATIONS MANAGER
Highest-paid employee
40$111,583$28,343
ELIZABETH MCHALEYINFORMATION PROGRAM DIR. THRU 11/24
Highest-paid employee
40$103,354$22,732
JERRY LOUISCREATING MARKETING MANAGER
Highest-paid employee
40$111,434$8,160
BARRY R SLOANECHAIRMAN/TREASURER
Trustee or director, Officer
5$0$0
MARTIN EDELMANVICE CHAIRMAN
Trustee or director, Officer
0.25$0$0
DAVID HW TURNERVICE CHAIRMAN
Trustee or director, Officer
5$0$0
HADLEY M FISHERSECRETARY
Trustee or director, Officer
5$0$0
DR MANUEL ALVAREZTRUSTEE
Trustee or director
5$0$0
GERRY BYRNETRUSTEE
Trustee or director
5$0$0
BETSY GOTBAUMTRUSTEE
Trustee or director
0.5$0$0
JAMES L NEDERLANDERTRUSTEE
Trustee or director
0.25$0$0
RICHARD J SALEMTRUSTEE
Trustee or director
0.75$0$0
DR MOSHE SHIKETRUSTEE
Trustee or director
0.25$0$0
990 for the year ended December 31, 2023: 13 people
NameTitleHours / weekCompensationOther / benefits
LUCRETIA HOLDENEXECUTIVE DIRECTOR
Officer
40$303,592$39,124
ELIZABETH MCHALEYINFORMATION PROGRAN DIRECTOR
Highest-paid employee
40$104,845$7,541
JERRY LOUISWEB DEVELOPER & GRAPHIC DESIGNER
Highest-paid employee
40$103,681$8,579
BARRY R SLOANECHAIRMAN/TREASURER
Trustee or director, Officer
5$0$0
MARTIN EDELMANVICE CHAIRMAN
Trustee or director, Officer
0.25$0$0
DAVID HW TURNERVICE CHAIRMAN
Trustee or director, Officer
0.75$0$0
HADLEY M FISHERSECRETARY
Trustee or director
0.25$0$0
DR MANNY ALVAREZTRUSTEE
Trustee or director
0.75$0$0
GERRY BYRNETRUSTEE
Trustee or director
0.75$0$0
BETSY GOTBAUMTRUSTEE
Trustee or director
0.25$0$0
JAMES L NEDERLANDERTRUSTEE
Trustee or director
0.25$0$0
RICHARD J SALEMTRUSTEE
Trustee or director
0.75$0$0
DR MOSHE SHIKETRUSTEE
Trustee or director
0.25$0$0

Address and contacts

Address (IRS master file)
750 LEXINGTON AVE STE 2400, NEW YORK, NY 10022-9815
Principal officer (990 for 2024)
BARRY R SLOANE, 750 LEXINGTON AVENUE 2400, NEW YORK, NY 10022
Signed the 990
BARRY R SLOANE, CHAIRMAN & TREASURER
Phone
(212) 915-1328
Return prepared by
PKF O'CONNOR DAVIES ADVISORY LLC

Mission

THE ZACHARY AND ELIZABETH M. FISHER CENTER FOR ALZHEIMER'S RESEARCH FOUNDATION IS DEDICATED TO ATTACKING THE SCOURGE OF ALZHEIMER'S DISEASE THROUGH A 3-PRONGED ASSAULT FOCUSED ON UNDERSTANDING THE CAUSE OF ALZHEIMER'S DISEASE (AD), IMPROVING THE CARE OF PEOPLE LIVING WITH THE DISEASE TO ENHANCE THEIR QUALITY OF LIFE AND THAT OF THEIR CAREGIVERS AND FAMILIES, AND FINDING A CURE.

990 for the year ended December 31, 2024

Program accomplishments

  • NYU SCHOOL OF MEDICINE - FISHER CLINICAL TRIALS:NYU LANGONE CLINICAL TRIALS CONDUCTING 20 TRIALS ON EXPERIMENTAL ALZHEIMER'S TREATMENTS. MARTIN SADOWSKI, MD, PHD, PROVIDES PERSONALIZED COUNSELING FOR PARTICIPANTS, HELPING THEM FIND THE MOST SUITABLE TRIAL.
    Expenses $5,516,050 · grants $5,400,000
  • ROCKEFELLER UNIVERSITY ARTIFICIAL INTELLIGENCE PROGRAM:FISHER AI PLATFORM FOR ALZHEIMER'S & NEURODEGENERATIVE RESEARCH. THIS INITIATIVE EQUIPS NEUROSCIENTISTS WITH CUTTING-EDGE AI TOOLS TO ACCELERATE DISCOVERIES IN ALZHEIMER'S RESEARCH.USING AI TO MAP CELL LOSS AND DECODE GENE NETWORKSWITH THE SPONSORSHIP OF THE FISHER CENTER FOR ALZHEIMER'S RESEARCH FOUNDATION, THE FISHER AI PLATFORM (LED BY DR. BARBANO) AND THE LABORATORY OF MOLECULAR BIOLOGY (LED BY DR. HEINTZ) APPLIED THEIR ADVANCED MFISH3D IMAGING TECHNIQUE TO TRACE HOW BRAIN CELLS ARE LOST OVER TIME IN ALZHEIMER'S DISEASE. THIS APPROACH ALLOWS RESEARCHERS TO SEE, IN THREE DIMENSIONS, WHICH TYPES OF BRAIN CELLS ARE MOST AFFECTED AND WHEN. IN PARALLEL, THE TEAM USED MACHINE LEARNING TO ANALYZE LARGE-SCALE GENETIC DATA, IDENTIFYING KEY NETWORKS OF GENES THAT MAY PLAY A ROLE IN BOTH ALZHEIMER'S AND HUNTINGTON'S DISEASE. THESE TOOLS PROVIDE A MORE DETAILED AND ACCURATE VIEW OF HOW THESE DISEASES PROGRESSAND WHERE TREATMENT MAY BE MOST EFFECTIVE.PREPARING FOR KISUNLA TREATMENT AT NYU LANGONEMARTIN SADOWSKI, MD, PHD, THE INAUGURAL INCUMBENT OF THE ZACHARY AND ELIZABETH M. FISHER PROFESSORSHIP IN NEURODEGENERATION AND ALZHEIMER'S DISEASE, WAS AN INVESTIGATOR ON ONE OF THE CLINICAL TRIALS OF KISUNLA (DONANEMAB), A NEW ALZHEIMER'S DRUG GRANTED FDA APPROVAL IN 2024. HE HAS SINCE DEVELOPED A TREATMENT PROTOCOL TO BE IMPLEMENTED ACROSS NYU LANGONE HEALTH. THE PROTOCOL OUTLINES HOW ELIGIBLE PATIENTS WITH EARLY-STAGE ALZHEIMER'S CAN ACCESS KINSUNLA AND BE MONITORED WHILE RECEIVING IT IN THERAPY. KISUNLA IS EXPECTED TO BE AVAILABLE TO NYU LANGONE PATIENTS BEGINNING IN JANUARY 2026.
    Expenses $5,107,454 · grants $5,000,000
  • ROCKEFELLER UNIVERSITY - FISHER CENTER LAB:NATHANIEL HEINTZ, PHD LEADS THE FISHER CENTER LAB AT THE ROCKEFELLER UNIVERSITY, HOME TO ONE OF THE LARGEST AND MOST ADVANCED ALZHEIMER'S RESEARCH FACILITIES IN THE WORLD. HIS TEAM STUDIES THE EARLIEST MOLECULAR EVENTS OF ALZHEIMER'SBEFORE AMYLOID-BETA (A) PLAQUES AND TAU TANGLES FORM. THEIR RESEARCH ON SELECTIVE CELLULAR VULNERABILITY AIMS TO UNCOVER WHY CERTAIN BRAIN CELLS DIE EARLIER THAN OTHERS, WHICH COULD BE KEY TO DEVELOPING TREATMENTS.AT THE FISHER CENTER LAB AT THE ROCKEFELLER UNIVERSITY, RESEARCHERS UNDER THE DIRECTION OF NATHANIEL HEINTZ, PHD, CONTINUE TO UNRAVEL THE EARLIEST MOLECULAR CHANGES IN ALZHEIMER'S DISEASE, AIMING TO UNDERSTAND WHAT MAKES CERTAIN BRAIN CELLS MOST VULNERABLE. BY PIONEERING CUTTING-EDGE MOLECULAR PROFILING TECHNIQUES, THEY ARE MAKING GROUNDBREAKING DISCOVERIES THAT PAVE THE WAY FOR BETTER TREATMENTS.RESEARCHERS AT THE FISHER CENTER LAB HAVE REFINED ADVANCED CELLULAR ANALYSIS METHODS TO EXAMINE HOW SPECIFIC BRAIN CELL TYPES ARE AFFECTED IN THE EARLIEST STAGES OF ALZHEIMER'S. THIS YEAR, THE TEAM: DEVELOPED NEW PROTOCOLS FOR ANALYZING HUMAN HIPPOCAMPUS AND ENTORHINAL CORTEX CELLS. IDENTIFIED EARLY-STAGE NEURON LOSS IN VULNERABLE BRAIN LAYERS, OFFERING INSIGHTS INTO DISEASE PROGRESSION. PROFILED 204 UNIQUE SAMPLES ACROSS 15 DIFFERENT CELL TYPES. UNCOVERED NEW TRANSCRIPTIONAL AND EPIGENETIC MARKERS THAT HELP EXPLAIN SELECTIVE CELLULAR VULNERABILITY.DATA-DRIVEN MILESTONE: THIS YEAR'S DATA HAVE CONFIRMED KNOWN PATTERNS OF DISEASE AND UNCOVERED NEW MOLECULAR EVENTS THAT SHED LIGHT ON HOW ALZHEIMER'S PROGRESSES AT THE CELLULAR LEVEL.UNDERSTANDING DISEASE PROGRESSION WITH NEW STAGING TOOLS:ONE CHALLENGE IN ALZHEIMER'S RESEARCH IS ACCURATELY DETERMINING DISEASE STAGE IN DONOR BRAIN SAMPLES. THE FISHER CENTER LAB HAS NOW DEVELOPED AN IN-HOUSE BRAAK STAGING PLATFORM, ENSURING THAT MOLECULAR FINDINGS ARE PROPERLY CONTEXTUALIZED.RECENT DISCOVERIES: THE EARLIEST DETECTABLE CHANGE OCCURS IN LAYERS 2/3 AND 4 OF THE CORTEX, REINFORCING THEIR SUSCEPTIBILITY. NO SIGNIFICANT LOSS WAS OBSERVED IN LAYER 5A PYRAMIDAL CELLS, A KEY DISTINCTION BETWEEN ALZHEIMER'S AND OTHER NEURODEGENERATIVE DISEASES. COMPUTATIONAL AND BIOINFORMATICS TOOLS ARE BEING APPLIED TO COMPARE MOLECULAR CHANGES IN VULNERABLE VS. RESISTANT NEURONS.
    Expenses $3,575,218 · grants $3,500,000
  • FISHER CENTER ASSISTANT PROFESSORSHIP (CAO):THE FISHER CENTER FOUNDATION INFORMATION PROGRAM DESCRIPTION AND ACCOMPLISHMENTSJUNYUE CAO, PHD RECIPIENT OF THE FISHER CENTER FOR ALZHEIMER'S RESEARCH FOUNDATION ASSISTANT PROFESSORSHIP, DR. CAO IS USING ADVANCED GENOMICS AND AI-DRIVEN ANALYSIS TO STUDY HOW GENE EXPRESSION AND EPIGENETICS INFLUENCE ALZHEIMER'S PROGRESSION.TRACKING BRAIN CELL CHANGES OVER TIMEJUNYUE CAO, PHD, WAS APPOINTED AS THE ROCKEFELLER UNIVERSITY'S FIRST FISHER CENTER FOUNDATION ASSISTANT PROFESSOR, A ROLE SUPPORTED BY THE ZACHARY AND ELIZABETH M. FISHER FUND FOR TRANSLATIONAL RESEARCH IN ALZHEIMER'S AND NEUROGENERATIVE DISEASE. HIS LAB DEVELOPED TRACKERSCI, A POWERFUL NEW TECHNIQUE THAT ALLOWS SCIENTISTS TO OBSERVE HOW BRAIN CELLS CHANGE ACROSS DIFFERENT STAGES OF LIFE. BY LABELING AND TRACKING TENS OF THOUSANDS OF INDIVIDUAL BRAIN CELLS, THE METHOD REVEALS HOW CERTAIN TYPES OF CELLS DECREASE WITH AGE WHILE OTHERS ESPECIALLY INFLAMMATORY CELLS BECOME MORE COMMON. THESE INSIGHTS COULD HELP RESEARCHERS BETTER UNDERSTAND THE EARLY BIOLOGICAL CHANGES THAT LEAD TO ALZHEIMER'S DISEASE. A PATENT APPLICATION FOR TRACKERSCI HAS BEEN FILED.
    Expenses $3,108,409 · grants $2,916,596 · revenue $3,085
  • NYU SCHOOL OF MEDICINE PROFESSORSHIP (SADOWSKI):DR. SADOWSKI THE ZACHARY AND ELIZABETH M. FISHER ENDOWED PROFESSOR IN NEURODEGENERATION AND ALZHEIMER'S DISEASE AT NYU, DR. SADOWSKI STUDIES GLIAL CELL DYSFUNCTION AND THE PROTECTIVE EFFECTS OF PEROXIREDOXIN 6, A POTENTIAL ALZHEIMER'S THERAPY.AT NYU GROSSMAN SCHOOL OF MEDICINE'S 2024 DEAN'S HONORS DAY, DR. SADOWSKI WAS FORMALLY RECOGNIZED WITH THE APPOINTMENT AS THE INAUGURAL ZACHARY AND ELIZABETH M. FISHER PROFESSOR OF NEURODEGENERATION AND ALZHEIMER'S DISEASE. THIS PRESTIGIOUS RECOGNITION CELEBRATES HIS DISTINGUISHED ACCOMPLISHMENTS IN ALZHEIMER'S RESEARCH AND HIS PROFOUND CONTRIBUTIONS TO NYU LANGONE'S ACADEMIC AND CLINICAL MISSION.THE NEW PROFESSORSHIP WILL SUPPORT DR. SADOWSKI'S ONGOING TRANSLATIONAL RESEARCH INTO THE CAUSES OF ALZHEIMER'S DISEASE. IT ALSO COINCIDES WITH THE LAUNCH OF THE FISHER CENTER ALZHEIMER'S CLINICAL TRIALS PROGRAM AT NYU LANGONE HEALTH, WHICH EXPANDS ACCESS TO EMERGING THERAPIES AND ENABLES INVESTIGATOR-LED TRIALS FOCUSED ON PREVENTION. AS BOTH A CLINICIAN AND RESEARCHER, DR. SADOWSKI CONTINUES TO ADVANCE THE FIELD AND BRING NEW HOPE TO PATIENTS AND FAMILIES AFFECTED BY ALZHEIMER'S.
    Expenses $3,329,638 · grants $2,663,394

What it must file and when

IRS records say it files Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N. Its accounting year ends in December, so each return is due on the 15th day of the 5th month after that.

Tax yearYear endedDueIRS public records
2025December 31, 2025May 15, 2026Not on file
2024December 31, 2024May 15, 2025990 on file
2023December 31, 2023May 15, 2024990 on file

IRS record

EIN
13-3859563
Tax-exempt status
501(c)(3): Charitable, religious, educational or scientific organization
Foundation status
Publicly supported organization (170(b)(1)(A)(vi))
Donations deductible (Pub 78)
Public charity, 50% deduction limit
Exempt since
1996
Accounting year ends
December
Files
Form 990 or 990-EZ
Category (NTEE)
Medical research (H99)
Assets (IRS master file)
$36,263,186
Income (IRS master file)
$17,116,383

Filing history

FormYear endedRevenueExpensesAssetsReturn
990December 2024$14,515,618$22,477,077$36,263,186XML
990December 2023$10,469,067$6,723,337$33,358,648XML
990December 2022$7,084,008$12,434,383$30,196,268IRS
990December 2021–––IRS
990December 2020–––IRS
990December 2018–––IRS

990-N: the IRS bulk file holds only the latest e-Postcard per organization; earlier years come from archived copies of that file since 2020 and can have gaps (the IRS e-Postcard search lists every one). 990, 990-EZ, 990-PF, 990-T: every e-filed return in the IRS e-file index since 2019; XML for the latest three processing years, amounts from the IRS Statistics of Income extracts before that. PDF copies and determination letters at the IRS (search EIN 13-3859563).

Questions about ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN

What is the EIN of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN?
The employer identification number (EIN) of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN is 13-3859563.
Is ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN tax-exempt?
Yes. The IRS lists it as tax-exempt under section 501(c)(3) since 1996.
Are donations to ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN tax-deductible?
Yes. It is listed in IRS Publication 78 (Public charity, 50% deduction limit).
Which annual return does ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN file?
Form 990 or 990-EZ. Based on its last return; a smaller organization may file the 990-N.
When is the next return of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN due?
The return for tax year 2025 (the year ending December 31, 2025) is due May 15, 2026. Form 8868 extends it by six months; the 990-N cannot be extended.
When did ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN last file with the IRS?
The latest return in the IRS public files is the 990 for the year ended December 2024.
Who is the principal officer of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN?
The 990 for the year ended December 31, 2024 names BARRY R SLOANE.
Who are the officers and directors of ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN?
The 990 for the year ended December 31, 2024 lists 14 people; 4 received compensation from the organization, the highest $336,398 (LUCRETIA HOLDEN, EXECUTIVE DIRECTOR).
How much revenue does ZACHARY AND ELIZABETH M FISHER CENTER FOR ALZHEIMERS RESEARCH FDN have?
On its 990 for the year ended December 31, 2024 it reported revenue of $14,515,618, expenses of $22,477,077 and total assets of $36,263,186 at year end.

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