﻿<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2025v4.0">
  <ReturnHeader binaryAttachmentCnt="0">
    <ReturnTs>2026-06-24T11:14:05-04:00</ReturnTs>
    <TaxPeriodEndDt>2025-12-31</TaxPeriodEndDt>
    <PreparerFirmGrp>
      <PreparerFirmEIN>562119415</PreparerFirmEIN>
      <PreparerFirmName>
        <BusinessNameLine1Txt>HOLLINGSWORTH AVENT AVERRE &amp; PURVIS PA</BusinessNameLine1Txt>
      </PreparerFirmName>
      <PreparerUSAddress>
        <AddressLine1Txt>300 W MILLBROOK RD</AddressLine1Txt>
        <CityNm>RALEIGH</CityNm>
        <StateAbbreviationCd>NC</StateAbbreviationCd>
        <ZIPCd>276094306</ZIPCd>
      </PreparerUSAddress>
    </PreparerFirmGrp>
    <ReturnTypeCd>990EZ</ReturnTypeCd>
    <TaxPeriodBeginDt>2025-01-01</TaxPeriodBeginDt>
    <Filer>
      <EIN>844555406</EIN>
      <BusinessName>
        <BusinessNameLine1Txt>PLASMINOGEN DEFICIENCY FOUNDATION</BusinessNameLine1Txt>
        <BusinessNameLine2Txt>INC</BusinessNameLine2Txt>
      </BusinessName>
      <BusinessNameControlTxt>PLAS</BusinessNameControlTxt>
      <PhoneNum>9198249543</PhoneNum>
      <USAddress>
        <AddressLine1Txt>203 PARK BLUFF DRIVE NORTH</AddressLine1Txt>
        <CityNm>CHAPEL HILL</CityNm>
        <StateAbbreviationCd>NC</StateAbbreviationCd>
        <ZIPCd>27517</ZIPCd>
      </USAddress>
    </Filer>
    <BusinessOfficerGrp>
      <PersonNm>REBECCA BIALAS</PersonNm>
      <PersonTitleTxt>CHAIRPERSON/DIRECTOR</PersonTitleTxt>
      <PhoneNum>9198249543</PhoneNum>
      <SignatureDt>2026-06-23</SignatureDt>
    </BusinessOfficerGrp>
    <PreparerPersonGrp>
      <PreparerPersonNm>CHARLES W AVERRE CPA</PreparerPersonNm>
      <PTIN>P00280366</PTIN>
      <PhoneNum>9198484100</PhoneNum>
      <PreparationDt>2026-06-23</PreparationDt>
    </PreparerPersonGrp>
    <TaxYr>2025</TaxYr>
    <BuildTS>2025-03-06 01:10:19Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCnt="3">
    <IRS990EZ documentId="RetDoc1" referenceDocumentId="RetDoc2">
      <MethodOfAccountingCashInd>X</MethodOfAccountingCashInd>
      <ScheduleBNotRequiredInd>X</ScheduleBNotRequiredInd>
      <WebsiteAddressTxt>WWW.PLASMINOGENDEFICIENCY.ORG</WebsiteAddressTxt>
      <Organization501c3Ind referenceDocumentId="RetDoc3">X</Organization501c3Ind>
      <TypeOfOrganizationCorpInd>X</TypeOfOrganizationCorpInd>
      <GrossReceiptsAmt>8640</GrossReceiptsAmt>
      <InfoInScheduleOPartIInd>X</InfoInScheduleOPartIInd>
      <ContributionsGiftsGrantsEtcAmt>6178</ContributionsGiftsGrantsEtcAmt>
      <InvestmentIncomeAmt>2462</InvestmentIncomeAmt>
      <TotalRevenueAmt>8640</TotalRevenueAmt>
      <OtherExpensesTotalAmt>5775</OtherExpensesTotalAmt>
      <TotalExpensesAmt>5775</TotalExpensesAmt>
      <ExcessOrDeficitForYearAmt>2865</ExcessOrDeficitForYearAmt>
      <NetAssetsOrFundBalancesBOYAmt>83409</NetAssetsOrFundBalancesBOYAmt>
      <NetAssetsOrFundBalancesEOYAmt>86274</NetAssetsOrFundBalancesEOYAmt>
      <CashSavingsAndInvestmentsGrp>
        <BOYAmt>83409</BOYAmt>
        <EOYAmt>86274</EOYAmt>
      </CashSavingsAndInvestmentsGrp>
      <Form990TotalAssetsGrp>
        <BOYAmt>83409</BOYAmt>
        <EOYAmt>86274</EOYAmt>
      </Form990TotalAssetsGrp>
      <NetAssetsOrFundBalancesGrp>
        <BOYAmt>83409</BOYAmt>
        <EOYAmt>86274</EOYAmt>
      </NetAssetsOrFundBalancesGrp>
      <InfoInScheduleOPartIIIInd>X</InfoInScheduleOPartIIIInd>
      <PrimaryExemptPurposeTxt>THE PLASMINOGEN DEFICIENCY FOUNDATION IS A 501(C)(3) NONPROFIT WHOSE MISSION IS TO ADVANCE THE CARE AND TREATMENT OF PATIENTS WITH PLASMINOGEN DEFICIENCY (PLGD) BY PROMOTING PUBLIC AWARENESS OF THE DISEASE THROUGH EDUCATION AND ADVOCACY, CREATING A COMMUNITY FOR THOSE AFFECTED BY PLGD, AND SUPPORTING RESEARCH TO ADDRESS THE CURRENT KNOWLEDGE GAPS IN PLASMINOGEN DEFICIENCY AND SUPPORT DEVELOPMENT OF SUSTAINABLE TREATMENTS.</PrimaryExemptPurposeTxt>
      <ProgramSrvcAccomplishmentGrp>
        <DescriptionProgramSrvcAccomTxt>PROMOTING PUBLIC AWARENESS, CREATING A COMMUNITY FOR THOSE AFFECTED.</DescriptionProgramSrvcAccomTxt>
        <ProgramServiceExpensesAmt>4872</ProgramServiceExpensesAmt>
      </ProgramSrvcAccomplishmentGrp>
      <TotalProgramServiceExpensesAmt>4872</TotalProgramServiceExpensesAmt>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>REBECCA BIALAS</PersonNm>
        <TitleTxt>CHAIRPERSON/</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>2.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>RYAN BIALAS</PersonNm>
        <TitleTxt>TREASURER/DI</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>2.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>SARAH BEIN</PersonNm>
        <TitleTxt>VICE CHAIR/D</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>1.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>CHRIS HOWELL</PersonNm>
        <TitleTxt>SECRETARY/DI</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>1.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>AMY SHAPIRO</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>1.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>AMY STEELE</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>1.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <OfficerDirectorTrusteeEmplGrp>
        <PersonNm>RENAE STRITZINGER</PersonNm>
        <TitleTxt>DIRECTOR</TitleTxt>
        <AverageHrsPerWkDevotedToPosRt>1.00</AverageHrsPerWkDevotedToPosRt>
        <CompensationAmt>0</CompensationAmt>
      </OfficerDirectorTrusteeEmplGrp>
      <ActivitiesNotPreviouslyRptInd>false</ActivitiesNotPreviouslyRptInd>
      <ChgMadeToOrgnzngDocNotRptInd>false</ChgMadeToOrgnzngDocNotRptInd>
      <OrganizationHadUBIInd>false</OrganizationHadUBIInd>
      <SubjectToProxyTaxInd>false</SubjectToProxyTaxInd>
      <OrganizationDissolvedEtcInd>false</OrganizationDissolvedEtcInd>
      <Form1120PolFiledInd>false</Form1120PolFiledInd>
      <MadeLoansToFromOfficersInd>false</MadeLoansToFromOfficersInd>
      <EngagedInExcessBenefitTransInd>false</EngagedInExcessBenefitTransInd>
      <ProhibitedTaxShelterTransInd>false</ProhibitedTaxShelterTransInd>
      <BooksInCareOfDetail>
        <PersonNm>REBECCA BIALAS</PersonNm>
        <USAddress>
          <AddressLine1Txt>203 PARK BLUFF DRIVE NORTH</AddressLine1Txt>
          <CityNm>CHAPEL HILL</CityNm>
          <StateAbbreviationCd>NC</StateAbbreviationCd>
          <ZIPCd>27517</ZIPCd>
        </USAddress>
        <PhoneNum>9198249543</PhoneNum>
      </BooksInCareOfDetail>
      <ForeignFinancialAccountInd>false</ForeignFinancialAccountInd>
      <ForeignOfficeInd>false</ForeignOfficeInd>
      <DonorAdvisedFndsInd>false</DonorAdvisedFndsInd>
      <OperateHospitalInd>false</OperateHospitalInd>
      <TanningServicesProvidedInd>false</TanningServicesProvidedInd>
      <RelatedOrganizationCtrlEntInd>false</RelatedOrganizationCtrlEntInd>
      <TransactionWithControlEntInd>false</TransactionWithControlEntInd>
      <PoliticalCampaignActyInd>false</PoliticalCampaignActyInd>
      <LobbyingActivitiesInd>false</LobbyingActivitiesInd>
      <SchoolOperatingInd>false</SchoolOperatingInd>
      <TrnsfrExmptNonChrtblRltdOrgInd>false</TrnsfrExmptNonChrtblRltdOrgInd>
      <PartVIOfCompOfHghstPdEmplTxt>NONE</PartVIOfCompOfHghstPdEmplTxt>
      <PartVIHghstPdCntrctProfSrvcTxt>NONE</PartVIHghstPdCntrctProfSrvcTxt>
      <FiledScheduleAInd>true</FiledScheduleAInd>
    </IRS990EZ>
    <IRS990ScheduleA documentId="RetDoc3">
      <PublicOrganization170Ind>X</PublicOrganization170Ind>
      <GiftsGrantsContriRcvd170Grp>
        <CurrentTaxYearMinus4YearsAmt>28591</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>4737</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>8034</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>6105</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>6178</CurrentTaxYearAmt>
        <TotalAmt>53645</TotalAmt>
      </GiftsGrantsContriRcvd170Grp>
      <TotalCalendarYear170Grp>
        <CurrentTaxYearMinus4YearsAmt>28591</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>4737</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>8034</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>6105</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>6178</CurrentTaxYearAmt>
        <TotalAmt>53645</TotalAmt>
      </TotalCalendarYear170Grp>
      <SubstantialContributorsTotAmt>34012</SubstantialContributorsTotAmt>
      <PublicSupportTotal170Amt>19633</PublicSupportTotal170Amt>
      <GrossInvestmentIncome170Grp>
        <CurrentTaxYearAmt>2461</CurrentTaxYearAmt>
        <TotalAmt>2461</TotalAmt>
      </GrossInvestmentIncome170Grp>
      <TotalSupportAmt>56106</TotalSupportAmt>
      <GrossReceiptsRltdActivitiesAmt>1</GrossReceiptsRltdActivitiesAmt>
      <PublicSupportCY170Pct>0.34990</PublicSupportCY170Pct>
      <ThirtyThrPctSuprtTestsCY170Ind>X</ThirtyThrPctSuprtTestsCY170Ind>
    </IRS990ScheduleA>
    <IRS990ScheduleO documentId="RetDoc2">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART I, LINE 16</FormAndLineReferenceDesc>
        <ExplanationTxt>EXPENSES WEBSITE 360 MARKETING 133 SUPPLIES 308 649 3,863 BOARD MEMBER INSURANCE 462 TOTAL 5,775</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990-EZ, PART III</FormAndLineReferenceDesc>
        <ExplanationTxt>THE PLASMINOGEN DEFICIENCY FOUNDATION IS A 501(C)(3) NONPROFIT WHOSE MISSION IS TO ADVANCE THE CARE AND TREATMENT OF PATIENTS WITH PLASMINOGEN DEFICIENCY (PLGD) BY PROMOTING PUBLIC AWARENESS OF THE DISEASE THROUGH EDUCATION AND ADVOCACY, CREATING A COMMUNITY FOR THOSE AFFECTED BY PLGD, AND SUPPORTING RESEARCH TO ADDRESS THE CURRENT KNOWLEDGE GAPS IN PLASMINOGEN DEFICIENCY AND SUPPORT DEVELOPMENT OF SUSTAINABLE TREATMENTS.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>