2025-12-26T09:32:39-05:00 2025-04-30 831352780 BOULDER CPA GROUP 1790 30TH ST STE 418 BOULDER CO 80301 990 2024-05-01 845178467 SOPHIE'S NEIGHBORHOOD SOPH 6462757881 3215 5TH ST BOULDER CO 80304 LAUREN ROSENBERG PRESIDENT-CEO 6462757881 2025-12-26 true true CAROL BAILIFF CPA P00347062 3034493060 2025-12-26 2024 2025-03-06 01:10:19Z LAUREN ROSENBERG PO BOX 7461 BOULDER CO 80306 935987 false X SOPHIESNEIGHBORHOOD.ORG X 2020 CO SOPHIE'S NEIGHBORHOOD IS A NONPROFIT DEDICATED TO FUNDRAISING FOR RESEARCH INTO THE DEVELOPMENT OF AN EFFECTIVE TREATMENT OR CURE FOR AN ULTRA RARE GENETIC DISORDER: MULTICENTRIC CARPOTARSAL OSTEOLYSIS (MCTO) 2 0 0 5 0 170543 212516 0 44304 -79347 13450 -82 228297 133087 242034 95522 0 0 0 1117 25300 13918 267334 109440 -39037 23647 996910 1020557 0 996910 1020557 X SOPHIE'S NEIGHBORHOOD IS A NONPROFIT DEDICATED TO FUNDRAISING FOR RESEARCH INTO THE DEVELOPMENT OF AN EFFECTIVE TREATMENT OR CURE FOR AN ULTRA RARE GENETIC DISORDER: MULTICENTRIC CARPOTARSAL OSTEOLYSIS (MCTO) false false 101120 95522 DURING THE FISCAL YEAR ENDING APRIL 2025, SOPHIE'S NEIGHBORHOOD FUNDED MAJOR RESEARCH INITIATIVES TO ADVANCE UNDERSTANDING AND TREATMENT OF MULTICENTRIC CARPO-TARSAL OSTEOLYSIS (MCTO) AN ULTRA RARE GENETIC BONE AND KIDNEY DISORDER. 1.ADVANCING MCTO DISEASE MECHANISMS THROUGH INNOVATIVE MOUSE MODELS SOPHIE'S NEIGHBORHOOD SUPPORTED RESEARCH AT HARVARD SCHOOL OF DENTAL MEDICINE INVESTIGATING BONE REMODELING ACTIVITY AND CELLULAR CHANGES MAFB MOUSE MODELS OF MCTO. THIS WORK INCLUDES TRANSCRIPTOMIC ANALYSES OF CELLS AND TISSUES WITHIN THE SKELETAL MICROENVIRONMENT TO UNCOVER MOLECULAR MECHANISMS DRIVING DISEASE PROGRESSION. 2.EXPANDING STEM CELL-BASED AND DEVELOPMENTAL MODELS OF MCTO IN COLLABORATION WITH BOSTON CHILDREN'S HOSPITAL, SOPHIE'S NEIGHBORHOOD CONTINUED TO FUND STUDIES ON MAFB AND DEVELOPMENTAL CHONDROGENESIS. THESE EFFORTS ADVANCE STEM CELL-BASED MODELS OF MCTO AND IDENTIFY KEY TRANSCRIPTIONAL NETWORKS INVOLVED IN BONE AND CARTILAGE DEVELOPMENT. 3.ESTABLISHING CRITICAL RESEARCH INFRASTRUCTURE FOR RARE DISEASE DISCOVERY SOPHIE'S NEIGHBORHOOD SUPPORTED THE CREATION AND ONGOING MAINTENANCE OF MCTO MOUSE LINES WITH SPECIFIC MAFB MUTATIONS AT THE JACKSON LABORATORY. THESE SPECIALIZED MODELS ENABLE RESEARCHERS TO TEST HYPOTHESES RELATED TO MAFB PROTEIN ACCUMULATION AND DISEASE PATHOLOGY, STRENGTHENING THE FOUNDATION FOR FUTURE THERAPEUTIC RESEARCH. 4.INITIATE ANTISENSE OLIGONUCLEOTIDE (ASO) DEVELOPMENT AND SCREENING TO EVALUATE THERAPEUTIC EFFICACY IN CELLULAR AND MOUSE MODELS, WITH THE GOAL OF REVERSING BONE AND KIDNEY PHENOTYPES ASSOCIATED WITH MCTO. 101120 true true false false false false false false false false false false false false false false false false false false false false false false false false false true false false false false false false false false false false false false false false false false false false false true 0 0 0 false false false false false false false false X 2 0 true false false false false false false true true false false false false false false false false false X LAUREN ROSENBERG 6462757881 3215 5TH ST BOULDER CO 80304 X BLAKE SEDBERRY BOARD MEMBER 2.00 X 0 0 0 MICHAEL WEINSTEIN BOARD MEMBER 2.00 X 0 0 0 HOSEA ROSENBERG VICE PRESIDE 5.00 X 0 0 0 LAUREN ROSENBERG PRESIDENT-CE 25.00 X 0 0 0 false false false 212516 212516 29900 29900 686335 795582 -109247 -109247 -109247 7236 7318 -82 -82 133087 -79429 95522 95522 263 263 3013 3013 5023 2511 2512 397 260 104 33 612 612 1295 777 259 259 SOFTWARE 1500 510 495 495 SUPPLIES 1001 341 330 330 WEBSITE EXPENSES 535 535 TELECOMMUNICATIONS 174 174 105 52 53 109440 101120 7203 1117 1 226264 334869 770646 685687 996910 1020557 0 0 X 996910 1020557 996910 1020557 996910 1020557 23647 X false false X 646658 252354 199497 170543 212516 1481568 646658 252354 199497 170543 212516 1481568 252577 1228991 1096 19326 30129 27464 29900 107915 164589 66435 7630 13450 7236 259340 1848823 1096 0.66470 X PART II, LINE 10 OTHER INCOME FROM FUNDRAISING 252,104 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED true HARVARD UNIVERSITY SCHOOL OF DENTAL MEDICINE 188 LONGWOOD AVENUE BOSTON MA 02115 042103580 41455 MEDICAL RESEARCH BOSTON CHILDRENS HOSPITAL 300 LONGWOOD AVENUE BOSTON MA 02115 042774441 501 C3 38221 MEDICAL RESEARCH RNASPIRE 10755 SCRIPPS POWAY PARKWAY 580 SAN DIEGO CA 92131 13000 2 1 SCHEDULE I, PAGE 1, PART I, LINE 2 OUR PI (PRIMARY INVESTIGATOR) IS ON OUR SCIENTIFIC ADVISORY BOARD AND PROVIDES US WITH A STATUS UPDATE ABOUT THE WORK ON MONTHLY CALLS. FORM 990, PAGE 2, PART III, LINE 4A DURING THE FISCAL YEAR ENDING APRIL 2025, SOPHIE'S NEIGHBORHOOD FUNDED MAJOR RESEARCH INITIATIVES TO ADVANCE UNDERSTANDING AND TREATMENT OF MULTICENTRIC CARPO-TARSAL OSTEOLYSIS (MCTO) AN ULTRA RARE GENETIC BONE AND KIDNEY DISORDER. 1.ADVANCING MCTO DISEASE MECHANISMS THROUGH INNOVATIVE MOUSE MODELS SOPHIE'S NEIGHBORHOOD SUPPORTED RESEARCH AT HARVARD SCHOOL OF DENTAL MEDICINE INVESTIGATING BONE REMODELING ACTIVITY AND CELLULAR CHANGES MAFB MOUSE MODELS OF MCTO. THIS WORK INCLUDES TRANSCRIPTOMIC ANALYSES OF CELLS AND TISSUES WITHIN THE SKELETAL MICROENVIRONMENT TO UNCOVER MOLECULAR MECHANISMS DRIVING DISEASE PROGRESSION. 2.EXPANDING STEM CELL-BASED AND DEVELOPMENTAL MODELS OF MCTO IN COLLABORATION WITH BOSTON CHILDREN'S HOSPITAL, SOPHIE'S NEIGHBORHOOD CONTINUED TO FUND STUDIES ON MAFB AND DEVELOPMENTAL CHONDROGENESIS. THESE EFFORTS ADVANCE STEM CELL-BASED MODELS OF MCTO AND IDENTIFY KEY TRANSCRIPTIONAL NETWORKS INVOLVED IN BONE AND CARTILAGE DEVELOPMENT. 3.ESTABLISHING CRITICAL RESEARCH INFRASTRUCTURE FOR RARE DISEASE DISCOVERY SOPHIE'S NEIGHBORHOOD SUPPORTED THE CREATION AND ONGOING MAINTENANCE OF MCTO MOUSE LINES WITH SPECIFIC MAFB MUTATIONS AT THE JACKSON LABORATORY. THESE SPECIALIZED MODELS ENABLE RESEARCHERS TO TEST HYPOTHESES RELATED TO MAFB PROTEIN ACCUMULATION AND DISEASE PATHOLOGY, STRENGTHENING THE FOUNDATION FOR FUTURE THERAPEUTIC RESEARCH. 4.INITIATE ANTISENSE OLIGONUCLEOTIDE (ASO) DEVELOPMENT AND SCREENING TO EVALUATE THERAPEUTIC EFFICACY IN CELLULAR AND MOUSE MODELS, WITH THE GOAL OF REVERSING BONE AND KIDNEY PHENOTYPES ASSOCIATED WITH MCTO. FORM 990, PAGE 6, PART VI, LINE 2 LAUREN ROSENBERG HOSEA ROSENBERG CEO VICE PRES. FAMILY RELATIONSHIP FORM 990, PAGE 6, PART VI, LINE 11B THE BOARD OF DIRECTORS REVIEWS TAX RETURNS BEFORE FILING FORM 990, PAGE 6, PART VI, LINE 19 GOVERNING DOCUMENTS ARE MADE AVAILBLE UPON WRITTEN REQUEST