2025-11-14T10:35:34-08:00 2024-12-31 872635810 Tovella Dowling PC 501 W Broadway Ste 1540 San Diego CA 92101 990 2024-01-01 883068255 SECUREBIO INC SECU 6153798149 1 Broadway 13-100 Cambridge MA 02142 Benjamin Mueller Executive Director 2025-11-14 true true Julie U Nguyen Esq P01881055 6199309332 2024 2025-03-06 01:10:19Z Benjamin Mueller 7324329 false X securebio.org X 2022 DE To reduce catastrophic risks from novel biotechnologies by conducting research on pandemic prevention, detection, and mitigation. 5 4 16 0 4245450 6816844 18529 326249 52990 174336 2156 6900 4319125 7324329 97000 0 725537 1372932 0 0 2128253 2781933 2853790 4251865 1465335 3072464 4855240 8470365 140051 682712 4715189 7787653 X To reduce catastrophic risks from novel biotechnologies by conducting research on pandemic prevention, detection, and mitigation. false false 1454990 As part of its work on the Nucleic Acid Observatory NAO project, the organization runs experiments to detect metagenomic sequences in wasterwater, with the ultimate aim of detecting new diseases before they grow exponentially in the community. In 2024, The NAO team conducted real-world biosurveillance of metropolitan sewage and airplane wastewater samples from selected US airports. It expects to scale its detection efforts in 2025. 1135237 As part of its SecureDNA project, the organization continued to make significant progress in 2024 on its gene synthesis screening software. The team released an alpha version and prepared for a public beta launch. This free software offers best-in-class performance in screening criteria and runs against a continuously updated hazard database. SecureDNA uniquely integrates with both vendor order flows and benchtop synthesizers. The organization successfully tested with major manufacturers and collaborated with leading gene synthesis companies. Two papers were prepared for submission to peer-reviewed journals, one on the screening system and another on its cryptographic architecture. These advancements further the organization's goal of securely monitoring synthetic DNA orders against various public health hazards. 748527 326249 The organization is developing measurement tools to assess AI systems' potential contribution to global catastrophic biological risks and creating mitigation strategies for when AI capabilities cross specific risk thresholds. Working with government and industry partners, they aim to de-risk upcoming AI model releases against severe biological hazards. The team has already published a pre-print on biorisks associated with model weight proliferation in Large Language Models, garnering major media attention. Their ongoing projects include research on risks from frontier models, developing benchmarks to evaluate large language models' biosecurity-relevant capabilities, creating task-based assessments for frontier systems' autonomous capabilities, and implementing technical interventions for risk mitigation, such as model unlearning of dual-use biological concepts and enhancing adversarial robustness against dual-use input prompts. 47305 The organization focuses on pandemic-proof personal protective equipment PPE that reliably shields essential workers against highly infectious agents without requiring fit-testing, ensuring the maintenance of critical infrastructure during pandemics. To enhance the availability and accessibility of this crucial equipment, the organization has undertaken several key initiatives. These include mapping critical infrastructure and essential workers, identifying cost-reduction strategies, advocating for public funds to build and maintain stockpiles, and exploring market mechanisms to support government efforts in stockpiling pandemic-proof PPE. Through these activities, the organization aims to strengthen pandemic preparedness and protect those who must continue working during health crises. As part of its work on the FAR-UVC project, the organization conducted an in-depth examination of the safety of far-UVC germicidal light throughout 2023. This comprehensive study involved convening a group of experts for both in-person and remote workshops over a 12-month period. The culmination of this extensive research was the release of a major paper on far-UVC safety, effectively concluding the organization's work on this project. While the organization designed a clinical study to further investigate the application of far-UVC technology, it determined that executing such a trial was not feasible given the available resources. This decision marked the completion of the organization's active involvement in the FAR-UVC research initiative. 47305 3386059 true true false false false false false false false false true false false false false true true false false false false false false false false false false true false true false false false false false false false false true false false false false false false false false true 37 0 true 16 true false false false false false false false 0 false false false false false false false X 5 4 false false true false false false false true true false false true true true true true false true true false DC IL MA X X Benjamin Mueller 6153798149 1 Broadway 13-100 Cambridge MA 02142 Jeffrey Kaufman NAO Project Lead 40.00 0.00 145000 0 6815 Michael McLaren Research Scientist 40.00 0.00 138299 0 12116 William Bradshaw Secretary 40.00 0.00 X 121513 0 10347 Seth Donoughe Research Scientist 40.00 0.00 122747 0 4225 Daniel Rice Research Scientist 40.00 0.00 113672 0 5207 Benjamin Mueller Treas Sep-Dec Executive Dir. 15.00 0.00 X X 53175 0 0 Vaishnav Sunil Treas Jan-Sep Treasurer 15.00 0.00 X 24397 0 526 Kevin Esvelt Director 0.50 0.00 X 0 0 0 Sawyer Bernath Director 2.00 0.00 X 0 0 0 Liv Boeree Director 1.00 0.00 X 0 0 0 Michael Specter Director 1.00 0.00 X 0 0 0 Christine Parthemore Director 1.00 0.00 X 0 0 0 718803 39236 5 false true false Hong-Wen Walther Chen 29 Oxford St 2 Somerville MA 02143 software development 196524 Leonard Foner 28 Cottage Ave Somerville MA 02144 software development 136000 Theia Vogel 12334 31st Ave NE 510 Seattle WA 98125 software development 115920 Steve Wooster 37971 SE Serban Rd Sandy OR 97055 software development 127353 4 6816844 58075 6816844 program consulting 541900 326249 326249 326249 174336 174336 0 0 0 0 0 0 0 Other Income 900099 6900 6900 6900 7324329 326249 181236 X 97000 97000 0 0 0 209958 136395 73563 0 986809 860452 126357 0 85181 77063 8118 90984 75810 15174 0 154901 82433 72468 38877 15077 23800 0 0 0 1836248 1801982 34266 3530 3530 217361 21230 196131 0 0 18191 18191 53244 14400 38844 0 6703 3674 3029 0 0 202079 168401 33678 3102 3102 legal settlement 175000 175000 dues & subscriptions 24305 1662 22643 equipment & technology 20502 8654 11848 equipment rental 12804 12804 15086 5492 9594 4251865 3386059 865806 0 3586153 5078605 0 382747 2580337 18529 130382 0 0 0 0 8078 1093369 427637 867811 665732 0 0 0 0 7231 4855240 8470365 140051 454679 228033 140051 682712 X 3579633 4306710 1135556 3480943 4715189 7787653 4855240 8470365 3072464 X false true X true false X 3436133 4245450 6816844 14498427 0 0 3436133 4245450 6816844 14498427 8514653 5983774 52990 174336 227326 0 2156 6900 9056 14734809 344778 X 0.00000 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 493717 212519 281198 296488 78694 217794 303164 136424 166740 665732 X 8368700 1044371 1044371 7324329 7324329 5296236 1044371 1044371 4251865 4251865 Part X : FIN48 Footnote The Organization is exempt from income taxes under Section 501(c)(3) of the Internal Revenue Code and accordingly, no provision for federal, state or local income taxes has been recorded. The Organization does not believe its financial statements include any uncertain tax positions. true UC Irvine 260 Aldrich Hall Irvine CA 92697 952226406 STATE OF CA 97000 0 RESEARCH 1 0 Grantmaker's Description of How Grants are Used The organization employs a robust grant monitoring process. Prior to awarding grants, the organization confirms the potential recipients' 501(c)(3) or government status and alignment with the organization's mission. Recipients are contractually obligated to use the grant funds for specified purposes. In some cases, the organization may require recipients to furnish post-disbursement progress reports and/or conduct check-ins with the organization to ensure appropriate usage of grant funds. Non-compliance with grant restrictions may lead to withholding or return of funds, in accordance with the terms of the applicable grant agreement. The organization maintains an active commitment to responsible stewardship of the funds it grants to ensure they are used for the intended charitable purposes. false false false false false false false false false Jeffrey Kaufman NAO Project Lead 145000 5075 1740 151815 Michael McLaren Research Scientist 138299 5147 6969 150415 X Office Equipment/Supplies 1 58075 Fair Market Value false false false Form 990, Part VI, Section A, Line 4 In 2024, the Organization amended its Certificate of Incorporation and Bylaws to grant the Board Chair the authority to cast a tie-breaking vote in the event of a deadlock on Board decisions. This change was made to ensure timely decision-making and avoid governance impasses. Form 990, Part VI, Section B, Line 11b A copy of the Form 990 was provided to the officers and directors for review and comment prior to filing. Form 990, Part VI, Section B, Line 12c Upon engagement, election, or hiring, directors, officers, and key employees agree to comply with the conflict of interest policy and to disclose any conflicts of interest, which are then handled in accordance with the policy. Form 990, Part VI, Section B, Line 15a It is the organization's policy that compensation of any director, officer, or key employee is reasonable. Determination of reasonableness entails gathering relevant market data followed by review, deliberation, and written approval by a disinterested board. Form 990, Part VI, Section B, Line 15b See response to Form 990, Part VI, Line 15a. Form 990, Part VI, Section C, Line 18 The organization's Form 1023 and Form 990 returns are accessible to the public through the Massachusetts Attorney General's Office, Non-Profit Organizations/Public Charities Division. The organization can also make such documents available upon written request. Form 990, Part VI, Section C, Line 19 Documents subject to public disclosure or inspection are accessible through the Massachusetts Attorney General's Office, Non-Profit Organizations/Public Charities Division or can be made available upon written request to the organization.