2024-11-12T11:41:40-08:00 2023-12-31 113344284 Piccirillo Lamont & Giammarese LLP 181 W Main Street Suite 101 Babylon NY 11702 990PF 2023-01-01 200284800 THE JAIN FOUNDATION INC JAIN 4258821492 9706 4TH AVENUE NE 101 SEATTLE WA 98115 LAURA RUFIBACH CO-PRESIDENT 2024-11-12 true true CAROL A ZOELLER CPA P01454472 6313762300 2023 2024-10-15 13:58:12Z X 79116385 X 26905326 17143 17143 17143 12149138 12149441 12149138 17065 39088672 12166281 17143 576230 59160 517070 437671 437671 23840 23840 44906 44906 13200 13200 75100 75100 152997 105608 105608 31650 31650 3263 3263 423075 423075 1887540 59160 1675383 3324301 3324301 5211841 59160 4999684 33876831 12107121 17143 622938 66782 66782 7500000 7500000 70537 81250 81250 25809429 48506460 71466943 1410 1410 1410 26504314 56155902 79116385 53404 36153 53404 36153 X 26450910 56119749 26450910 56119749 26504314 56155902 26450910 33876831 303 60328044 4208295 56119749 BERKSHIRE HATHAWAY INC B D 2012-09-28 2023-03-02 1999721 58 1999663 1999663 BERKSHIRE HATHAWAY INC B D 2016-01-26 2023-08-10 10149720 245 10149475 10149475 12149138 168289 168289 168289 163907 15000 178907 X 485 10133 10133 false false false false false false false true true NY true false false false false true JAIN-FOUNDATION.ORG LAURA RUFIBACH 4258821492 9706 4TH AVENUE SUITE 101 SEATTLE WA 98115 false false false false false false false false false false false false false false false false false false false false false false AJIT JAIN ISLAND DRIVE RYE NY 10580 Director 3.00 0 INDRIMA JAIN ISLAND DRIVE RYE NY 10580 Director 1.00 0 ASHKAY JAIN ISLAND DRIVE RYE NY 10580 CEO 40.00 197199 DOUG ALBRECHT PHD 9706 4TH AVE NE STE 101 SEATTLE WA 89115 CO-PRESIDENT 40.00 189516 LAURA RUFIBACH 9706 4TH AVE NE STE 101 SEATTLE WA 89115 CO-PRESIDENT 40.00 189515 SARAH S EMMONS 2127 33RD AVE W SEATTLE WA 98199 DIR. PATIENT 40.00 150000 LAURIE R LONG 9513 EVANSTON AVE N SEATTLE WA 98103 OFFICE MGMT 40.00 69432 BRADLEY A WILLIAMS 12034 15TH AVE NE 104 SEATTLE WA 98125 DIR. RESEARCH 40.00 106896 KANAN LATHIA 7620 NE 32ND ST MEDINA WA 98039 ASSOC DIR RESEARCH 40.00 69231 NONE While the focus of the Jain Foundation is Dysferlinopathy (LGMD2B/R2/Miyoshi Myopathy1), the resulting scientific advances and collaborations that we make have a broader impact on human health through their relevance to other muscle disorders, degenerative diseases, and normal aging. The Foundation takes a hands-on approach to funding. We closely monitor the progress of every project we fund and keep track of results and shifting timelines through quarterly conference calls with researchers and site visits. We also support internal programs and initiatives. Our goal is to fund all possible approaches to a cure and help with patient diagnosis to ensure that treatments reach those who need them. 0 Contract Research Organizations ($94,763): In 2023, we continued working with Contract Research Organizations (CROs) as an integral part of our therapy development program. CROs are companies that serve the drug development industry and provide specialized knowledge and infrastructure focused on drug discovery, such as robotics and large compound libraries. There are many drugs in development (some even FDA approved) for other diseases that may be useful in Dysferlinopathy. To evaluate their benefit in dysferlinopathy, we need specific assays that predict their effects in our disease. The process of developing assays is tedious, time consuming and difficult to publish, making them unsuitable for researchers at academic institutions. Our strategy is to learn about dysferlin in academic laboratories and then apply what we learn to the development of assays and evaluate drugs at CROs. CRO projects are completed at a much faster pace than academic projects, because there is more focused ex 94763 Clinical Trial readiness and Community Engagement ($281,512): Dysferlinopathy is very rare. An important goal of the Jain Foundation is to prepare the dysferlinopathy patient community for clinical trials. There are many aspects to being clinical trial ready, including patient identification, community engagement, patient education, and identification of outcome measures. For patient identification we have a patient registry called the Dysferlin Registry that contains 1200+ individuals verified to have dysferlinopathy. In addition, we have a diagnosis pipeline that provides access to genetic testing for those who need it and ensures that barriers to genetic testing dont prevent people with dysferlinopathy from accessing the Dysferlin Registry. In 2023, we added 81 dysferlinopathy patients to the registry. Community engagement and education includes interactions with the patient community, clinicians, LGMD advocacy groups, Industry and the FDA. Our patient education and engagement effor 281512 Tools for Researchers ($226,425): As a recognized leader in the field, we continue to receive queries and help researchers access reagents such as antibodies and cell lines that are required for their research. In addition, we actively identify and fund the development of research tools and resources needed to advance the dysferlin field. The Jain Foundation is committed to developing and providing frequently required reagents, the availability of which helps accelerate research. We contributed dysferlin DNA to public repositories and have helped companies develop antibodies to dysferlin so that they can be easily obtained. We built a library of cell lines that are useful to study dysferlin deficiency. In 2023, we continued to maintain large colonies of mice at the custom mouse breeding facility at Jackson Laboratories (USA) and Ozgene ARC (Australia) for use in dysferlin research. Information about these resources is disseminated to researchers through e-mails and through the Foundati 226425 57698748 3784989 0 61483737 0 61483737 922256 60561481 3028074 3028074 168289 168289 2859785 2859785 2859785 4999684 4999684 2859785 2017222 1654250 1594562 1659525 1628423 8553982 4999684 0 2859785 2139899 10693881 0 2017222 8676659 1654250 1594562 1659525 1628423 2139899 LAURA RUFIBACH 9706 4TH AVE NE STE 101 SEATTLE WA 98115 4258821492 LRUFIBACH@JAIN-FOUNDATION.ORG SEE FOUNDATION WEBSITE JAIN-FOUNDATION.ORG THERE ARE NO SUBMISSION DEADLINES. THE EXPLICIT GOAL OF THE JAIN FOUNDATION IS TO EXPEDITE DEVELOPMENT OF A TREATMENT OR CURE FOR LGMD2B/MIYOSHI. ANY PROPOSED PROJECT THAT DOES NOT HAVE APPLICATION TO THIS DISEASE WILL NOT BE CONSIDERED. UNIV OF BRITISH COLUMBIA DR BERNATC 103-6190 AGRONOMY ROAD VANCOUVER BRITISH COLUMBIA CA V6T 1Z3 NONE NC SCIENTIFIC RESEARCH GRANT 123675 UNIV OF MARYLAND DR BLOCH 655 W BALTIMORE STREET BALTIMORE MD 21201 NONE PC SCIENTIC RESEARCH GRANT 265014 DUKE UNIV DR BURSAC 100 SCIENCE DR 1138 CIEMAS DURHAM NC 27708 NONE PC SCIENTIFIC RESEARCH GRANT 242314 CAMDND DR GAITONDE DR DASTUR 194 ROAD 15 SION MUMBAI MAHARASHTRA IN 400022 NONE NC SCIENTIFIC RESEARCH GRANT 25450 ROCKEFELLER UNIV DR CHAIT DR ROUT 1230 YORK AVENUE NEW YORK NY 10065 NONE PC SCIENTIFIC RESEARCH GRANT 47300 CURTIN UNIV DR JACKAMAN GPO BOX U1987 PERTH WESTERN AUSTRALIA AS 6845 NONE NC SCIENTIFIC RESEARCH GRANT 31036 CHILDRENS RESEARCH INSTITUTE DR JAI 111 MICHIGAN AVE NW WASHINGTON DC 20010 NONE PC SCIENTIFIC RESEARCH GRANT 76799 NY UNIVERSITY DR KANG GROSSMAN SCH OF MED 550 FIRST AVE NEW YORK NY 10016 NONE PC SCIENTIFIC RESEARCH GRANT 200000 UNIV OF QUEENSLAND DR LAUNIKONIS MCGREGOR BLDG RM 312 ST LUCIA QLD AS 4072 NONE NC SCIENTIFIC RESEARCH GRANT 57998 SANFORD BURNHAM PREBYS INST DR PURI BLDG 12 1ST FL 10901 N TORREY PINES LA JOLLA CA 92037 NONE PC SCIENTIFIC RESEARCH GRANT 56763 NEWCASTLE UNIV DR STRAUB INTL CENTRE FOR LIFE CENTRAL PKWY NEWCASTLE UPON TYNE TYNE AND WEAR UK NE1 3BZ NONE NC SCIENTIFIC RESEARCH GRANT 544699 BRIGHAM YOUNG UNIV DR VAN RY C100 BENSON SCIENCE BLDG PROVO UT 84602 NONE PC SCIENTIFIC RESEARCH GRANT 171260 THE UNIV OF MELBOURNE DR WATT R 602 L 6 W MED BLDG 181 GRATTON ST PARKVILLE VICTORIA AS 3010 NONE NC SCIENTIFIC RESEARCH GRANT 109007 OHIO STATE UNIV DR WEISLEDER 473 W 10TH AVE COLUMBUS OH 43210 NONE PC SCIENTIFIC RESEARCH GRANT 94011 LA TROBE UNIV DR MURPHY PLENTY RD KINGSBURY DR BUNDOORA VIC AS 3086 NONE NC SCIENTIFIC RESEARCH GRANT 71909 MASS INST OF TECH DR GUARENTE 77 MASSACHUSETTS AVE 68-280 CAMBRIDGE MA 02139 NONE PC SCIENTIFIC RESEARCH GRANT 272262 TEXAS TECH UNIV DR BRYAN SUTTON 3601 4TH ST MS 6551 LUBBOCK TX 79423 NONE PC SCIENTIFIC RESEARCH GRANT 29335 CASIMIR LLC DR WOODS 68 EVERGREEN ST STE 1 KINGSTON MA 02364 NONE NC SCIENTIC RESEARCH GRANT 10785 LAVAL UNIV DR TREMBLAY 2705 BOUL LAURIER RM P0300 QUEBEC QC QUEBEC CA GIV 4G2 NONE NC SCIENTIFIC RESEARCH GRANT 28276 PROJECT 8P FOUNDATION 787 SEVENTH AVE - 31ST FL NEW YORK NY 10019 NONE PC SCIENTIFIC RESEARCH GRANT 600000 SAN CAMILLO IRCCS DR BARRESI VIA ALBERONI 70 VENEZIA LIDO VENEZIA LIDO IT 30126 NONE NC SCIENTIFIC RESEARCH GRANT 12358 NEWCASTLE UNIV DR MANERA INTL CENTRE FOR LIFE CENTRAL PKWY NEWCASTLE UPON TYNE TYNE AND WEAR UK NE1 3BZ NONE NC SCIENTIFIC RESEARCH GRANT 39934 UNIVERSITY OF ROCHESTER DR ANDERSON 601 ELMWOOD AVE BOX CVRI ROCHESTER NY 14642 NONE NC SCIENTIFIC RESEARCH GRANT 175075 WAYNE STATE UNIV DR DRESCHER 1200 HOLDEN ST RM 259 LANDE MRB DETROIT MI 48202 NONE PC SCIENTIFIC RESEARCH GRANT 39041 3324301 14 17143 18 12149138 UNIV OF NEWCASTLE 18 17065 12183346 12183346 false false false false false false false false false false X X 1 WARREN BUFFETT 3555 FARNAM STREET SUITE 1440 OMAHA NE 68131 26905326 X 1 50 SHARES BERKSHIRE HATHAWAY INC CL A STOCK 26905326 2023-08-15 ACCOUNTING FEES 13200 0 0 13200 LEGAL FEES 44906 0 0 44906 OTHER ASSETS 1410 1410 1410 DECREASE IN THE VALUE OF CORPORATE STOCK 4208295 BANK SERVICE CHARGE 115 115 BUSINESS LICENSE EXPENSE 128 128 CHARLES RIVER DISCOVERY SERVICE 47725 47725 CLINICAL OUTCOME STUDY 11383 11383 COMPUTER EQUIPMENT 4482 4482 CRO JACKSON LABORATORIES 200178 200178 CRO OZGEN 5845 5845 GIFTS 133 133 INSURANCE 1504 1504 LIFE & DISABILTIY INSURANCE 3196 3196 MEMBERSHIP DUES 220 220 MISCELLANEOUS 546 546 NY CHARITIES 750 750 OFFICE EXPENSES 2096 2096 OUTSIDE COMPUTER SERVICES 5151 5151 PATIENT DIAGNOSTICS 1190 1190 PATIENT RECRUITMENT 8108 8108 PAYROLL TAXES 75129 75129 PFML INSURANCE 3983 3983 POSTAGE, SHIPPING AND DELIVERY 2386 2386 RESEARCH TOOLS 1450 1450 SPONSORSHIP 19545 19545 TELEPHONE AND INTERNET 5047 5047 WEBSITE DESIGN AND SOFTWARE 22785 22785 UNIV OF NEWCASTLE 17065 BASIS ADJUSTMENT 303 CONSULTING FEES 75100 0 0 75100 EXCISE TAX 152997