2024-11-10T22:09:07-07:00 2024-06-30 990 2023-07-01 383225425 ALTERNATING HEMIPLEGIA OF CHILDHOOD FOUNDATION INC ALTE 2000 Town Center Suite 1900 Southfield MI 48075 Gene Andrasco Treasurer 8475306918 2024-11-10 1 2023 2024-10-15 13:58:12Z Vicky Platt 2451 Chas Drive Rolling Meadows IL 60008 336590 0 X ahckids.org X 1995 MI Our mission is to find the cause(s) of Alternating AHC), develop effective treatments and ultimately find a cure, while providing support to the families and children with AHC by funding research to accomplish these goals 9 9 0 150 125576 0 115270 197687 0 0 41428 38367 193299 87209 349997 323263 31488 127478 0 0 0 0 0 0 0 167308 93024 198796 220502 151201 102761 1359089 1537672 0 0 1359089 1537672 Our mission is to find the cause(s) of AHC, develop effective treatments and ultimately a cure, while providing support to the families and children with AHC by funding research to accomplish these goals. Through research, education and family support we have One Mission - END AHC. 0 0 42132 42132 0 Grant given to Dr. Alfred L. George, Jr at the Northwestern University to determine if molecular mechanisms underlying ATP1A3-associated neurological disorders are amenable to antisense oligonucleotide therapeutic strategies. This research also aims to demonstrate the electrophysiological effects of antisense-oligonucleotide (ASO) directed knock down of ATP1A3 in human neurons. 62500 62500 0 Contribute to the purchase of a specialized Microscope for Dr Kathy Sweadner's use in AHC-related projects at Mass General Research Institute 11822 11822 0 The AHCF contributed to research at Brown University lead by Anne Hart that developed C. elegans AHC ATP1A3 models. Aim 1 of the project generated custom C. elegans lines using CRISPR-Cas9-based genome editing of the C. elegans ATP1A3, called eat-6, to create AHC models and controls for three patient alleles: D801N, E815K, and L839P. Aim 2 examined the consequences of inserting these patient missense alleles using multiple assessments of eat-6 function: hatch/growth, NMJ sensitivity to aldicarb, egg laying, and pharyngeal pumping rates. Here, provide a summary of results, along with a set of four Supplementary Files that contain additional analysis, figures and raw data. 37102 37102 0 See Schedule O, Statement 1 37102 37102 0 153556 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 X 9 9 0 0 0 0 0 0 0 1 0 0 0 1 1 1 0 0 0 0 0 0 MI X X X X Sharon Ciccodicola 3136637772 2000 Town Center Suite 1900 Southfield MI 48074 X Lynn Egan Director 1 0 X 0 0 0 Kathy Sharo Director 1 0 X 0 0 0 Mollie Erpenbeck Director 1 0 X 0 0 0 Sharon Ciccodicola Director 1 0 X 0 0 0 Bill Gerber Director 1 0 X 0 0 0 Vicky Platt President 4 0 X 0 0 0 Gene Andrasco Treasurer 4 0 X 0 0 0 Heather Gates Vice-President of Education & Family Support 4 0 X 0 0 0 Cate Cohen Secretary 4 0 X 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 197687 0 197687 0 38367 0 38367 0 0 0 0 0 0 0 0 0 0 0 0 0 97028 0 13327 83701 83701 0 3508 0 3508 0 3508 323263 0 125576 0 53953 53953 62500 62500 11025 11025 35750 35750 13089 13089 6339 6339 1381 1381 26078 26078 2276 2276 Other - License / Taxes & Fees 320 0 320 0 Other -Marketing 7791 0 7791 0 220502 153556 66946 0 137440 301909 1221649 1235763 1359089 1537672 0 0 X 0 0 0 0 1359089 1537672 1359089 1537672 1359089 1537672 102761 75822 0 0 0 0 X 0 0 0 X 23371 13917 13255 115270 136162 301975 8567 5752 6974 8020 3508 32821 0 0 0 0 0 0 0 0 0 31938 19669 20229 123290 139670 334796 0 0 0 0 0 0 0 0 0 0 0 0 334796 7084 5158 21318 41428 38367 113355 0 0 0 7084 5158 21318 41428 38367 113355 0 0 0 0 0 0 39022 24827 41547 164718 178037 448151 0.74706 0.74054 0.25294 0.25946 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED Europe (including Iceland and Greenland) Project "Oxytahane", which is a clinical trial I will conduct here at the Salpetriere with the help of URC (Clinical Research Unit) to test the efficacy of high-flow oxygen to treat the paroxysmal motor events in alternating hemiplegia of childhood 11025 Wire Transfer 0 0 1 0 0 0 0 0 0 Virtual Walk 76959 0 76959 0 0 0 0 0 4600 Golf Outing 17825 0 17825 0 0 4844 1878 0 162 0 94784 0 94784 0 0 4844 1878 0 4762 11484 83300 1 Brown University 69 Brown Street 2nd FL Providence RI 02912 050258809 11822 Medical Research 1 0 Payment made to Simon & Nina Frost to help fund a Microscope for Kathleen J Sweadner, Ph.D Assoc Prof (M) Neurosurgery, Mass General Research Institute and Associate Professor of Cellular and Molecular Physiology in the Department of Neurosurgery Harvard Medical School 1 62500 Schedule I, Part I, Line 2 Schedule !, Part I, Line 2: Grant requests come into our Executive Committee, are reviewed by our Medical Advisory Board, and approved by the Board of Directors. Each grant has a requirement that progress reports are sent to the AHCF Board. Form 990, Part VI, Section A, Line 8b The AHCF Board of Directors records and/or takes minute for each meeting, however not all committees have consistently recorded or taken minutes for all committee meetings Form 990, Part VI, Section B, Line 11b Copies of 990 forms are saved on a shared cloud storage site for the entire AHCF Board of Directors to review Form 990, Part VI, Section C, Line 18 The form 990 and supporting schedules are available on the Guidestar website guidestar.org Form 990, Part VI, Section C, Line 19 The financial statements, conflict of interest policy and form 990 with related schedules may be accessed by contacting Sharon Ciccodicola at 2000 Town Center Suite 1900 Southfield, MI 48075