2024-10-22T12:58:28-07:00 2023-12-31 872635810 Tovella Dowling PC 600 W Broadway Ste 660 San Diego San Diego CA 92101 990 2023-01-01 883068255 SECUREBIO INC SECU 6158668656 1 Broadway 13-100 Cambridge MA 02142 Benjamin Mueller Executive Director 2024-10-22 true true Julie U Nguyen Esq P01881055 6199309332 2023 2024-10-15 13:58:12Z Benjamin Mueller 1 Broadway 13-100 Cambridge MA 02142 4319125 false X securebio.org X 2022 DE To reduce catastrophic risks from novel biotechnologies by conducting research on pandemic prevention, detection, and mitigation. 3 3 8 3 0 3436133 4245450 18529 52990 2156 3436133 4319125 0 0 32059 725537 0 0 154220 2128253 186279 2853790 3249854 1465335 3261854 4855240 12000 140051 3249854 4715189 X To reduce catastrophic risks from novel biotechnologies by conducting research on pandemic prevention, detection, and mitigation. false false 1342801 As part of its SecureDNA project, the organization made significant progress in 2023 on its gene synthesis screening software. The team released an alpha version and prepared for a public beta launch. This free software offers best-in-class performance in screening criteria and runs against a continuously updated hazard database. SecureDNA uniquely integrates with both vendor order flows and benchtop synthesizers. The organization successfully tested with major manufacturers and collaborated with leading gene synthesis companies in the US and China. Two papers were prepared for submission to Nature, one on the screening system and another on its cryptographic architecture. These advancements further the organization's goal of securely monitoring synthetic DNA orders against various public health hazards. 752022 As part of its work on the Nucleic Acid Observatory (NAO) project, the organization runs experiments to detect metagenomic sequences in wasterwater, with the ultimate aim of detecting new diseases before they grow exponentially in the community. In 2023, The NAO team conducted a major experiment, collecting wastewater samples from a prominent US airport and one of the nation's largest wastewater treatment plants. This rich dataset is slated for analysis in the coming year. The team expanded its research output, publishing a paper on pathogen abundance as a function of disease prevalence, building upon their previous report on the topic. Additionally, they released a paper on virus-like phagemids, which were designed and built in-house to experimentally characterize wastewater-based pathogen monitoring systems. To accelerate disease detection capabilities in wastewater, the organization initiated work on a more immediate NAO pilot project, focusing on specific pathogens rather than the full-scale, pathogen-agnostic approach of the primary NAO initiative. 108255 As part of its work on the FAR-UVC project, the organization conducted an in-depth examination of the safety of far-UVC germicidal light throughout 2023. This comprehensive study involved convening a group of experts for both in-person and remote workshops over a 12-month period. The culmination of this extensive research was the release of a major paper on far-UVC safety, effectively concluding the organization's work on this project. While the organization designed a clinical study to further investigate the application of far-UVC technology, it determined that executing such a trial was not feasible given the available resources. This decision marked the completion of the organization's active involvement in the FAR-UVC research initiative. 120418 2323496 true true false false false false false false false false true false false false false true true false false false false false false false false false false false false false false false false false false false false false true false false false false false false false false true 16 0 true 8 true false false false false false false false 0 false false false false false false false X 3 3 false false false false false false false true true false false true true true true true false false false false DC MA X X AAF CPAs 7745129062 465 Waverley Oaks Road Suite 420 Waltham MA 02452 Vaishnav Sunil Treasurer 4.00 0.00 X 8400 0 0 Benjamin Mueller Executive Dir. 1.00 0.00 X X 0 0 0 Kevin Esvelt Director 0.50 0.00 X 0 0 0 Sawyer Bernath Director 0.50 0.00 X 0 0 0 William Bradshaw Secretary 4.00 0.00 X 0 0 0 8400 0 false false false Hong-Wen Walther Chen 29 Oxford St 2 Somerville MA 02143 software development 128790 Leonard Foner 28 Cottage Ave Somerville MA 02144 software development 288000 Nomadic Workplace LLC 312 W 2nd St Unit A1230 Casper WY 82601 software development 210669 Theia Vogel 12334 31st Ave NE 510 Seattle WA 98125 software development 169395 4 4245450 444795 4245450 program consulting 541900 18529 18529 18529 52990 52990 0 0 0 0 0 0 0 Other Income 900099 2156 2156 2156 4319125 18529 55146 X 0 0 0 0 8400 8400 0 621430 474010 147420 0 48640 37179 11461 47067 36083 10984 0 119898 15858 104040 31709 31709 0 0 0 1544973 1533665 11308 0 138707 28092 110615 0 0 0 53386 26474 26912 0 7477 6692 785 0 0 191506 145947 45559 1825 1825 equipment & technology 14210 465 13745 meals 9484 1032 8452 payroll processing fees 6560 5110 1450 filing fees 2878 2698 180 5640 1791 3849 2853790 2323496 530294 0 2562780 3586153 0 382747 18529 0 0 0 0 0 1093369 225558 699074 867811 0 0 0 0 0 3261854 4855240 12000 140051 12000 140051 X 3249854 3579633 1135556 3249854 4715189 3261854 4855240 1465335 X true X true X true false X 3436133 4245450 7681583 0 0 3436133 4245450 7681583 3419325 4262258 52990 52990 0 2156 2156 7736729 18529 X 0.00000 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 493717 113776 379941 296488 35991 260497 303164 75791 227373 867811 X 5361138 1042013 1042013 4319125 4319125 3895803 1042013 1042013 2853790 2853790 Part X : FIN48 Footnote The organization is a nonprofit corporation exempt from federal income tax under Internal Revenue Code Section 501c3 and from state income taxes under equivalent statutes, except on unrelated business income. Therefore, these financial statements contain no provision for such taxes. Informational returns are filed annually with federal and state taxing authorities. The organization is not aware of any transactions that would affect its tax-exempt status. The organization believes that it has appropriate support for any tax positions taken and as such, does not have any uncertain tax positions that are material to the financial statements. The organization had no unrecognized tax benefits as of December 31, 2022. X Leasehold Improvements 1 115843 fair market value X Computer Equipment 1 238317 Fair Market Value X Lab Equipment 1 6083 Fair Market Value X Office Equipment/Supplies 1 84552 Fair Market Value false false false Form 990, Part III, Line 4d OTHER PROGRAM SERVICES 4: The organization focuses on pandemic-proof personal protective equipment (PPE) that reliably shields essential workers against highly infectious agents without requiring fit-testing, ensuring the maintenance of critical infrastructure during pandemics. To enhance the availability and accessibility of this crucial equipment, the organization has undertaken several key initiatives. These include mapping critical infrastructure and essential workers, identifying cost-reduction strategies, advocating for public funds to build and maintain stockpiles, and exploring market mechanisms to support government efforts in stockpiling pandemic-proof PPE. Through these activities, the organization aims to strengthen pandemic preparedness and protect those who must continue working during health crises. OTHER PROGRAM SERVICES 5: The organization is developing measurement tools to assess AI systems' potential contribution to global catastrophic biological risks and creating mitigation strategies for when AI capabilities cross specific risk thresholds. Working with government and industry partners, they aim to de-risk upcoming AI model releases against severe biological hazards. The team has already published a pre-print on biorisks associated with model weight proliferation in Large Language Models, garnering major media attention. Their ongoing projects include research on risks from frontier models, developing benchmarks to evaluate large language models' biosecurity-relevant capabilities, creating task-based assessments for frontier systems' autonomous capabilities, and implementing technical interventions for risk mitigation, such as model unlearning of dual-use biological concepts and enhancing adversarial robustness against dual-use input prompts. Form 990, Part VI, Section B, Line 11b A copy of the Form 990 was provided to the officers and directors for review and comment prior to filing. Form 990, Part VI, Section B, Line 12c Upon engagement, election, or hiring, directors, officers, and key employees agree to comply with the conflict of interest policy and to disclose any conflicts of interest, which are then handled in accordance with the policy. Form 990, Part VI, Section C, Line 18 The organization's Form 1023 and Form 990 returns are accessible to the public through the Massachusetts Attorney General's Office, Non-Profit Organizations/Public Charities Division. The organization can also make such documents available upon written request. Form 990, Part VI, Section C, Line 19 Documents subject to public disclosure or inspection are accessible through the Massachusetts Attorney General's Office, Non-Profit Organizations/Public Charities Division or can be made available upon written request to the organization.