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        <FormAndLineReferenceDesc>FORM 990, PART I, LINE 1</FormAndLineReferenceDesc>
        <ExplanationTxt>PRION ALLIANCE, INC. AIMS TO CATALYZE THE DEVELOPMENT OF A TREATMENT OR CURE FOR HUMAN PRION DISEASES BY FUNDING, ORGANIZING AND PROMOTING SCIENTIFIC RESEARCH. OUR ORGANIZATION SUPPORTS RESEARCH DIRECTED AT UNDERSTANDING PRION DISEASE BIOLOGY, DISCOVERING AND TESTING THERAPEUTICS, AND DEVELOPING NOVEL LAB AND COMPUTATIONAL METHODOLOGIES NEEDED FOR FURTHERING THIS RESEARCH. OUR OPERATIONAL MODEL IS TO RAISE FUNDS AND DISBURSE THESE TO THE MOST WORTHY SCIENTIFIC PROJECTS, WITH A VIEW TO THE PROJECTS' RELEVANCE TO OUR ULTIMATE GOAL OF A TREATMENT OR CURE, AS WELL AS TO THE PROJECTS' ABILITY TO LEVERAGE PRION ALLIANCE, INC SEED FUNDING IN ORDER TO PURSUE OUTSIDE FUNDING SOURCES FOR CONTINUED RESEARCH. WE ALSO STRIVE TO BRING TOGETHER TOP SCIENTIFIC MINDS TO SHARE DATA, METHODOLOGY, AND FINDINGS IN A SPIRIT OF OPENNESS AND COLLABORATION.</ExplanationTxt>
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        <ExplanationTxt>SONIA VALLABH AND ERIC MINIKEL ARE MARRIED.</ExplanationTxt>
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        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>DRAFT 990 IS CIRCULATED TO DIRECTORS VIA EMAIL FOR REVIEW AND APPROVAL PRIOR TO FILING.</ExplanationTxt>
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        <ExplanationTxt>DIRECTORS ARE REQUIRED TO DISCLOSE COI IN WRITING. ANNUALLY, DIRECTORS ARE ASKED TO CONFIRM THEIR COI DISCLOSURE LIST.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>ORGANIZATIONAL DOCUMENTS ARE AVAILABLE ON OUR WEBSITE PRIONALLIANCE.ORG</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART IX, LINE 11G</FormAndLineReferenceDesc>
        <ExplanationTxt>RESEARCH: PROGRAM SERVICE EXPENSES 464,387. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 464,387.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART XII, LINE 2C:</FormAndLineReferenceDesc>
        <ExplanationTxt>THIS PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART XI, LINE 8:</FormAndLineReferenceDesc>
        <ExplanationTxt>THERE WAS A PRIOR PERIOD ADJUSTMENT RECORDED IN 2023 THAT RELATED TO THE PERIOD FOR 2020 2022 ONCE AN AUDIT WAS COMPLETED. FOR 2021, OPENING EQUITY CHANGED BY $1,965, ACCOUNTS RECEIVABLE INCREASED BY $21,850, REVENUE INCREASED BY $1,850 AND RESEARCH EXPENSE DECREASED BY $21,965. FOR 2022, ACCOUNTS RECEIVABLE INCREASED BY $55,000, REVENUE DECREASED BY $33,150, ACCRUED EXPENSES AND RESEARCH EXPENSE BOTH INCREASED BY $7,300 AND NET ASSETS INCREASED BY $21,850.</ExplanationTxt>
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</Return>