2024-11-14T18:18:10-06:00 2023-12-31 454205322 HW LLP 16133 VENTURA BLVD STE 700 ENCINO CA 914362406 990 2023-01-01 851457272 EPIGENETIC CLOCK DEVELOPMENT FOUNDATION EPIG 8189213980 1124 W CARSON ST MRL BLDG 3RD FLO TORRANCE CA 90502 ROBERT BROOKE EXECUTIVE DIRECTOR 8189213980 2024-11-14 1 0 LOUIS HAMEL P00392169 8189213980 2024-11-14 2023 2024-10-15 13:58:12Z ROBERT BROOKE 1124 W CARSON ST MRL BLDG 3RD FLOOR TORRANCE CA 90502 2885392 0 X WWW.CLOCKFOUNDATION.ORG X 2020 CA THE EPIGENETIC CLOCK DEVELOPMENT FOUNDATION ("CLOCK FOUNDATION") WAS FORMED TO ENABLE RIGOROUS MEDICAL RESEARCH ON AGING AND LONGEVITY. OUR RESEARCH MAINLY INVOLVES USE AND DEVELOPMENT OF NEW AGING BIOMARKERS KNOWN AS EPIGENETIC CLOCKS FOR TESTING THE EFFECTIVENESS OF LONGEVITY TREATMENTS WITHIN PRECLINICAL AND CLINICAL STUDIES. 3 3 6 0 0 0 0 6600 1580545 1921950 116 289 2013146 956553 3593807 2885392 0 0 0 0 381782 284545 0 0 0 3009302 3168916 3391084 3453461 202723 -568069 1193723 954701 532743 945905 660980 8796 X THE CLOCK FOUNDATION WAS FORMED FOR THE SPECIFIC AND PRIMARY PURPOSE OF CONDUCTING MEDICAL RESEARCH ON AGING AND AGE-RELATED DISEASES. DEVELOPING THE EPIGENETIC AGING CLOCK INTO A USEFUL TECHNOLOGY WILL REQUIRE MEDICAL RESEARCH ON AGING AND AGE-RELATED DISEASES. CONSEQUENTLY, THE ACTIVITY WILL ADVANCE CLOCK FOUNDATION'S SPECIFIC PURPOSE OF CONDUCTING MEDICAL RESEARCH ON AGING AND AGE-RELATED DISEASES. IF THE MEDICAL RESEARCH OF THE CLOCK FOUNDATION IS SUCCESSFUL AND THE FDA APPROVES THE CLOCK FOUNDATION'S TESTING METHOD, MANY NEW DRUGS OR TREATMENTS THAT ARE ABLE TO REVERSE EPIGENETIC AGING COULD THEN BE FORMALLY APPROVED BY THE FDA FOR THE TREATMENT OF AGING AND FOR USE IN PREVENTATIVE MEDICINE. 0 0 95167 33600 INTERNAL RESEARCH PROGRAM:SINCE INCEPTION WE HAVE FOCUSED ON DEVELOPMENT OF EPIGENETIC CLOCKS AS A KEY ENABLING TECHNOLOGY FOR THE FIELD. WE ARE A SMALL TEAM OF DEDICATED RESEARCHERS, AND THIS YEAR HIRED ADDITIONAL PART-TIME OPERATIONAL, ADMIN, AND FINANCE STAFF, ALONG WITH A NEW RESEARCH ASSOCIATE. WE CONTINUED TO WORK CLOSELY WITH OUR SCIENTIFIC ADVISORS, ESPECIALLY ON DEVELOPMENT OF NOVEL TESTING APPROACHES. THE HORVATH MAMMALIAN ARRAY, A KEY ENABLING TECHNOLOGY FOR TRANSLATIONAL AGING RESEARCH, WAS PUBLISHED IN NATURE COMMUNICATIONS, WITH ADDITIONAL PAPERS PUBLISHED IN 2023 IN SCIENCE AND NATURE AGING. ADDITIONAL PAPERS HAVE BEEN RELEASED ON DOGS IN PNAS, CATS, HORSES, SHEEP, MARSUPIALS, NAKED MOLE RATS, AND MANY OTHERS. THE PAPERS DESCRIBE THE DISCOVERY OF UNIVERSAL MAMMALIAN AGING CLOCKS & EPIGENETIC PREDICTORS OF MAXIMUM LIFESPAN. 2378281 2844903 EXTERNAL RESEARCH COLLABORATIONS: INTERVENTIONAL LONGEVITY STUDIES WE CONDUCTED MANY NEW INTERVENTIONAL STUDIES, FOR CLINICAL TRIALS AND ALSO PRECLINICAL STUDIES. THIS INCLUDES STUDIES ON PLASMAPHARESIS, YOUNG PLASMA TREATMENT, STEM CELL EXOSOMES, BONE MARROW TRANSPLANTS, UMBILICAL CORD PLASMA, ANTIRETROVIRAL TREATMENTS, AND A SENOLYTIC GENE THERAPY. WE ALSO COMPLETED ANALYSIS FOR A >1,000-PERSON LONGITUDINAL STUDY OF TESTOSTERONE TREATMENT, ANALYZING ITS EFFECTS ON ESTABLISHED CLINICAL & FUNCTIONAL AGING BIOMARKERS. MECHANISMS OF AGING STUDIES THERE WERE MANY NOTABLE MECHANISTIC STUDIES THIS PAST YEAR INCLUDING FROM THE HOCHEDLINGER LAB ON THE ROLE OF CELLULAR HETEROGENEITY IN EPIGENETIC CLOCK RESULTS, THE DALEY LAB ON LIN28'S ROLE IN REPROGRAMMING, THE LEVIN LAB ON LIMB REGENERATION, THE GLADYSHEV LAB ON BONE MARROW TRANSPLANTS. 939075 6889 OTHER PROGRAM SERVICES 939075 6889 3412523 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 4 0 6 0 0 0 0 0 0 0 0 0 0 0 X 3 3 0 0 0 0 0 0 0 1 1 0 0 0 1 1 1 1 1 1 1 0 CA X X ROBERT BROOKE 5138699793 1124 W CARSON ST BLDG 3RD TORRANCE CA 90502 ROBERT BROOKE EXECUTIVE DIRECTOR 40.00 X X 120000 0 0 STEFAN HORVATH DIRECTOR, CHAIRMAN 40.00 X 120000 0 0 DEAN PRISSMAN DIRECTOR 0.00 X 0 0 0 240000 0 0 2 0 0 0 VUGENE LLC 625 KENMOOR AVE SUITE 301 PMB 965 GRAND RAPIDS MI 49546 BIOINFORMATICS CONSULTING 115000 1 6600 6600 FEE FOR SERVICE INCOME 541700 1921950 1921950 1921950 289 289 SALES 541700 922953 922953 CONTRACT INCOME 541700 33600 33600 956553 2885392 2878792 0 0 240000 240000 17860 17860 26685 26685 30881 30881 10057 10057 64407 64407 18425 18425 27 27 69583 69583 942 942 54196 54196 SPONSORED EPIGENETIC TE 2378281 2378281 RESEARCH & DEVELOPMENT 363914 363914 TREATMENT TESTING SERVI 95167 95167 SOFTWARE DEVELOPMENT SE 43196 43196 39840 39840 3453461 3412523 40938 0 638291 157312 510227 766383 9955 245 35250 30761 1193723 954701 532743 945905 532743 945905 X 660980 8796 660980 8796 1193723 954701 -568069 -84115 0 X 0 0 0 X HARBOR UCLA MEDICAL CENTER TORRANCE CA RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED FORM 990, PART VI, SECTION B, LINE 11B FINANCIALS ARE PREPARED BY A BOOKKEEPER WITH INPUT FROM A CERTIFIED PUBLIC ACCOUNTANT. TAX ACCOUNTANTS PREPARE THE FILING. EXECUTIVE DIRECTOR REVIEWS AND RECEIVES INPUT FROM LEGAL COUNSEL PRIOR TO FILING. FORM 990, PART VI, SECTION B, LINE 12C OFFICERS, DIRECTORS, EMPLOYEES AND VOLUNTEERS OF EPIGENETIC CLOCKDEVELOPMENT FOUNDATION ARE ENCOURAGED TO BRING ANY ALLEGED UNLAWFULACTIVITY, POLICY OR PRACTICE TO THE ATTENION OF EPIGENETIC CLOCK DEVELOPMENT FOUNDATION. A PROTEST, CONCERN OR COMPLAINT SHALL BE MADE INWRITING TO THE PRESIDENT OF EPIGENETIC CLOCK DEVELOPMENT FOUNDATION. FORM 990, PART VI, SECTION B, LINE 15 BOARD MEMBERS AND DONOR ORGANIZATIONS ARE MADE AWARE OF AND ABLE TO REVIEWEXECUTIVE AND KEY EMPLOYEE COMPENSATION THROUGH INDEPENDENT REPORTS ANDTHROUGH APPROVAL OF ANNUAL BUDGETS. BOARD MEMBERS AND DONOR ORGANIZATIONS ARE MADE AWARE OF AND ABLE TO REVIEW EXECUTIVE AND KEY EMPLOYEE COMPENSATION THROUGH INDEPENDENT REPORTS AND THROUGH APPROVAL OF ANNUAL BUDGETS. FORM 990, PART VI, SECTION C, LINE 19 THE DOCUMENTS ARE MADE AVAILABLE UPON REQUEST.