2024-08-15T14:31:19-05:00 2023-09-30 042713795 MEYERS BROTHERS KALICKA PC 330 WHITNEY AVE SUITE 800 HOLYOKE MA 01040 990 2022-10-01 571183126 PIONEER VALLEY LIFE SCIENCES INSTITUTE OF BAYSTATE MEDICAL & UMASS AMHERSTINC PION 4137947833 3601 MAIN STREET SPRINGFIELD MA 01001 RAYMOND MCCARTHY SVP, CFO, TREASURER 4137947833 2024-08-13 1 0 RUDY M D'AGOSTINO P00962620 4135368510 2024-08-12 2022 2024-08-08 14:25:15Z RAYMOND MCCARTHY 3601 MAIN STREET SPRINGFIELD MA 01107 81262 0 X PVLSI.ORG X 2004 MA IMPROVE HUMAN HEALTH BY DEVELOPING NEW APPROACHES FOR THE DIAGNOSIS & TREATMENT OF DISEASE. 7 7 0 7 0 0 78598 81240 0 0 0 0 0 22 78598 81262 0 0 0 0 0 0 0 0 0 241703 227665 241703 227665 -163105 -146403 982741 867391 271146 302199 711595 565192 X TO IMPROVE HUMAN HEALTH BY DEVELOPING CREATIVE NEW APPROACHES FOR THE DIAGNOSIS AND TREATMENT OF DISEASE. 0 0 71826 BREAST REGISTRYDESCRIPTION: ANALYSIS-READY DATASETS WITH PATIENT CHARACTERISTICS TOGETHER WITH TREATMENTS AND OUTCOMES ARE ESSENTIAL TO IDENTIFY SUCCESSES IN CLINICAL MANAGEMENT AND AREAS WHERE LIMITATIONS EXIST. WE HAVE CREATED A PROSPECTIVE REGISTRY FOCUSED ON BREAST CANCER. THIS RESOURCE INCLUDES A DETAILED SURVEY OF LIFESTYLE, HEALTH HISTORY ALONG WITH DIAGNOSTIC AND TREATMENT INFORMATION. TISSUE SPECIMENS ARE ALSO AVAILABLE FOR ALL THE PARTICIPANTS. THE REGISTRY PROVIDES ACCESS TO PATIENT DATA IN A PROSPECTIVE FASHION TO FACILITATE EVALUATIONS OF CLINICAL OUTCOMES.ACCOMPLISHMENTS: PRESENT ENROLLMENT TOTAL IS 1,600 PARTICIPANTS. 71826 BREAST CELL REPOSITORY DESCRIPTION: NORMAL CELLS FROM A DIVERSE COHORT OF PATIENTS IS NEEDED TO IDENTIFY THE CELLULAR MECHANISMS RESPONSIBLE FOR THE WIDE VARIATION IN RESPONSES TO THERAPIES AMONG INDIVIDUALS. THIS EFFORT FOCUSES ON CREATION OF NORMAL BREAST EPITHELIAL CELLS THAT REFLECT THE VARIATION IN THE POPULATION OF WOMEN. METHODS ARE USED TO EXPAND THE CELLS IN VITRO PROVIDING A VERSATILE SOURCE FOR TESTING DIFFERENCES IN SENSITIVITY TO ENVIRONMENTAL CONTAMINANTS AND THERAPEUTIC COMPOUNDS. ACCOMPLISHMENTS: BREAST CELLS FROM 500 INDIVIDUALS AND GROWING. PROCEDURES TO IMMORTALIZE NORMAL BREAST CELLS FROM MOST PATIENTS HAVE BEEN ESTABLISHED. WE HAVE ESTABLISHED IMMORTALIZED CELL LINES FROM NORMAL BREAST EPITHELIUM FROM 17 DONORS REPRESENTING DIVERSE BREAST CANCER RISK. THE CELL LINES ARE GENETICALLY STABLE AND UNIQUE BASED ON GENETIC FINGERPRINTING. THESE ARE BEING USED TO DETERMINE DIFFERENCES IN SUSCEPTIBILITY TO ONCOGENIC TRANSFORMATION CAUSED BY CHEMICALS AND ALTERED CELL SIGNALING. 71827 BIOSPECIMEN RESOURCES & MOLECULAR ANALYSIS FACILITYDESCRIPTION: THE FACILITY MAINTAINS THE EQUIPMENT AND PERSONNEL TO PROVIDE HISTOLOGICAL SERVICES. THIS GROUP ALSO ASSISTS INVESTIGATORS WITH MAINTAINING IRB APPROVALS FOR TISSUE PROCUREMENT. ACCOMPLISHMENTS: SUPPORT SERVICES (HISTOLOGY, MOLECULAR ANALYSES) HAS BEEN USED BY INVESTIGATORS FROM UMASS AMHERST, UMASS MEDICAL SCHOOL, BAYSTATE HEALTH SYSTEMS AS WELL AS SERVING OTHER ACADEMIC SCIENTISTS. 215479 1 1 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 X 7 7 0 0 0 0 0 1 0 1 1 0 0 1 1 0 0 0 0 0 0 0 MA X LAURIE MARTIN 4137940000 BAYSTATE HEALTH INC 280 CHESTNUT ST SPRINGFIELD MA 01199 X PETER REINHART PHD VICE CHAIR 5.00 X X 0 0 0 PETER FRIEDMANN CHAIR 5.00 X X 0 0 0 PATRICK SHEEHY DIRECTOR; TREASURER 5.00 X X 0 0 0 MICHAEL MALONE PHD DIRECTOR (END 7/2023) 5.00 X 0 0 0 ANDREW MANGELS DIRECTOR 5.00 X 0 0 0 KEITH PARENT DIRECTOR 5.00 X 0 0 0 JAY STEINGRUB DIRECTOR 5.00 X 0 0 0 LAURA VANDENBERG DIRECTOR (START 7/2023) 5.00 X 0 0 0 RAYMOND MCCARTHY CFO 5.00 X 0 0 0 0 0 0 0 0 0 0 0 81240 81240 22 22 81262 0 0 22 3388 3388 69440 69440 145354 145354 8798 8798 MEMBERSHIP DUES 682 682 UTILITIES 3 3 227665 215479 12186 0 334641 324092 3887941 3500425 532870 387516 115230 155783 982741 867391 1965 4128 269181 298071 271146 302199 X 711595 565192 711595 565192 982741 867391 -146403 0 X 0 0 0 X 5 5 145961 78598 81240 305809 5 5 145961 78598 81240 305809 305809 22 22 305831 0.99990 1.00000 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 3304577 2917061 387516 583364 583364 0 387516 DUE FROM RELATED PARTY 155783 155783 DUE TO RELATED PARTY 298071 298071 FORM 990, PART VI, SECTION A, LINE 7A CEO OF BAYSTATE HEALTH, INC. AND PRESIDENT OF UNIVERSITY OF MASSACHUSETTS EACH SELECT 3 DIRECTORS. FORM 990, PART VI, SECTION B, LINE 11B THE FORM 990 IS REVIEWED IN DETAIL BY THE FINANCE AND AUDIT COMMITTEE AND THEREAFTER MADE AVAILABLE TO THE ENTIRE BOARD OF DIRECTORS. FORM 990, PART VI, SECTION B, LINE 12 ALL DIRECTORS ARE REQUIRED TO DISCLOSE ANY CONFLICT AT THE TIME THE CONFLICT ARISES AND REFRAIN FROM PARTICIPATING IN ANY DECISION REGARDING THAT INTEREST. FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION MAKES ITS GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS AVAILABLE UPON REQUEST PART VI: SECTION B, GOVERNING POLICIES A POLICY HAS BEEN DRAFTED THAT REQUIRES THE ORGANIZATION TO FOLLOW THE GOVERNING POLICIES OF BAYSTATE HEALTH, INC. & UMASS AMHERST, INC.